The correct spelling of the 7th authors' name is Mona Watany.
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| http://dx.doi.org/10.1007/s11033-020-05564-7 | DOI Listing |
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The role of microRNA in the regulation of hepatic metabolism and energy-expensive processes in the hibernating dormouse.
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Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.
The garden dormouse (Eliomys quercinus) is a fat-storing mammal that undergoes annual periods of hibernation to mitigate the effects of food scarcity, low ambient temperatures, and reduced photoperiod that characterize winter. Like other hibernating species, this animal suppresses its metabolic rate by downregulating nonessential genes and processes in order to prolong available energy stores and limit waste accumulation throughout the season. MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that bind to mRNA and mediate post-transcriptional suppression, making miRNA ideal for modulating widespread changes in gene expression, including global downregulation typified by metabolic rate depression.
View Article and Find Full Text PDFCRISPR/Cas12a regulated preassembled bulb-shaped G-quadruplex signal unit for FL/CM dual-mode ultrasensitive detection of miRNA-155.
Talanta
December 2024
Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing, 400044, PR China; Chongqing Key Laboratory of Bio-perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing, 400044, PR China. Electronic address:
High sensitivity and specificity in microRNA detection are of great significance for early cancer screening. This study employed a pre-assembled bulb-shaped G-quadruplex signal unit (G4MB) as a novel and efficient label-free probe. The products amplified by the miRNA-155-targeted exponential amplification reaction (EXPAR) activated the trans-cleavage activity of CRISPR/Cas12a, disrupting the G4MB structure to achieve dual-channel fluorescence/colorimetric (FL/CM) inverse signal output.
View Article and Find Full Text PDFProfiling host- and parasite-derived miRNAs associated with Strongylus vulgaris infection in horses.
Vet Parasitol
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Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
The equine bloodworm, Strongylus vulgaris, is a common and highly pathogenic parasite in horses due to its migratory life cycle involving the intestinal arteries. Current diagnostic techniques cannot detect the prepatent migrating stages of S. vulgaris, highlighting the need for new biomarkers.
View Article and Find Full Text PDFCorrigendum: Longitudinal associations between microRNAs and weight in the diabetes prevention program.
Front Endocrinol (Lausanne)
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Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
[This corrects the article DOI: 10.3389/fendo.2024.
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