Study on repairing canine mandibular defect with porous Mg-Sr alloy combined with Mg-Sr alloy membrane.

To discuss the feasibility of the application of porous MgSr alloy combined with MgSr alloy membrane in the repair of mandibular defects in dogs. The second and third mandibular premolars on both sides were extracted from six dogs. The model of mandible buccal fenestration bone defects were prepared after the sockets healed. Twelve bone defects were randomly divided into groups A and B, then MgSr alloy was implanted in bone defects of group A and covered by MgSr alloy membrane while MgSr alloy was implanted in bone defects of group B and covered by mineralized collagen membrane. Bone defects observed on cone beam computed tomographic images and comparing the gray value of the two groups after 4, 8 and 12 weeks. After 12 weeks, the healing of bone defects were evaluated by gross observation, X-ray microscopes and histological observation of hard tissue. Bone defects in each group were repaired. At 8 and 12 weeks, the gray value of group A was higher than that of group B (<0.05). At 12 weeks, the bone volume fraction of group A was higher than that of group B (<0.05). The newly woven bone in group A is thick and arranged staggered, which was better than that of group B. Porous MgSr alloy combined with MgSr alloy membrane could further promote the repair of mandibular defects, and obtain good osteogenic effect.