The event horizon telescope (EHT) is expected to soon produce polarimetric images of the supermassive black hole at the centre of the neighbouring galaxy M87. There are indications that this black hole is rapidly spinning. General relativity predicts that such a high-spin black hole has an emergent conformal symmetry near its event horizon. In this paper, we use this symmetry to analytically predict the polarized near-horizon emissions to be seen at the EHT and find a distinctive pattern of whorls aligned with the spin.
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http://dx.doi.org/10.1098/rspa.2019.0618 | DOI Listing |
Cardiovasc Diagn Ther
December 2024
Department of Cardiology, University Heart & Vascular Center, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Background: Cardiovascular disease (CVD) remains the leading cause of death in pregnant and peripartal women in western countries. Physiological changes during pregnancy can lead to cardiovascular complications in the mother; women with pre-existing heart disease may not tolerate these changes well, increasing their susceptibility to adverse cardiovascular outcomes during pregnancy. The aim of this study is to characterize pregnancy-induced changes in cardiac function, biomarker concentrations and cardiovascular outcomes in women with CVD during pregnancy at a tertiary care hospital in Germany.
View Article and Find Full Text PDFCell Commun Signal
January 2025
School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Endothelial-mesenchymal transition (EndMT) is defined as an important process of cellular differentiation by which endothelial cells (ECs) are prone to lose their characteristics and transform into mesenchymal cells. During EndMT, reduced expression of endothelial adhesion molecules disrupts intercellular adhesion, triggering cytoskeletal reorganization and mesenchymal transition. Numerous studies have proved that EndMT is a multifaceted biological event driven primarily by cytokines such as TGF-β, TNF-α, and IL-1β, alongside signaling pathways like WNT, Smad, MEK-ERK, and Notch.
View Article and Find Full Text PDFNPJ Vaccines
January 2025
Community Medical Services Division, Clalit Health Services, Tel-Aviv, Israel.
Evidence regarding the high-dose (HD) vaccine's relative vaccine effectiveness (rVE) and absolute benefit in reducing influenza-related hospitalizations compared to the standard-dose (SD) vaccine is warranted. We estimated the adjusted rVE and the number needed to vaccinate (NNV) of the HD vaccine compared to the SD vaccine among Clalit Health Services members aged ≥65 years. Among 418,603 and 393,125 members vaccinated in the 2022-2023 and 2023-2024 influenza seasons, the adjusted rVE was 27% (95% CI: -12% to 61%) for 2022-2023 and 7% (95% CI: -36% to 42%) for 2023-2024, with NNV to prevent one hospitalization event being 2262 (95% CI: 1004 to ∞) and 7662 (95% CI: 1293 to ∞), respectively.
View Article and Find Full Text PDFBackground: Data-driven models are at the mercy of the data upon which they are built. Poorly configured models can lead to misleading conclusions. Here we introduce a framework called Goldilocks for carefully configuring data-driven modelling analyses to remain in the Goldilocks Zone - features that are not too weak (in terms of disease signal), and model (hyper)parameters that are not too strong (with respect to available training data).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University College London, London, United Kingdom.
Background: Data-driven models are at the mercy of the data upon which they are built. Poorly configured models can lead to misleading conclusions. Here we introduce a framework called Goldilocks for carefully configuring data-driven modelling analyses to remain in the Goldilocks Zone - features that are not too weak (in terms of disease signal), and model (hyper)parameters that are not too strong (with respect to available training data).
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