Background: Diarrheagenic (DEC) is a significant cause of gastroenteritis and a major public health problem. This study investigates the prevalence and the antibiotic resistance patterns of DEC that were isolated from infectious diarrhea samples of pediatric patients from central Iran.
Patients And Methods: Pediatric diarrhea samples were collected from 230 pediatric patients visiting the hospital. pathotypes were diagnosed by using conventional culture methods and PCR. Antibiotic resistance profiles, the frequency of multi-drug resistance (MDR), and the phenotypic and genotypic characteristics of extended spectrum-β-lactamase (ESBL), AmpC and integron-associated genes were analyzed.
Results: Of the 230 samples of infectious diarrhea, 91 (39.5%) produced isolates. Of these, 32 cases (35.1%) were identified as DEC by culture and PCR. The frequency of the pathotypes obtained was as follows: EAEC 11/32 (34.3%), EPEC 9/32 (28.1%), ETEC 6/32 (18.7%), EIEC 3/32 (9.3%), and EHEC 3/32 (9.3%). The antibiotic resistance rates were greater for nalidixic acid (30/32; 93.7%), ampicillin (29/32; 90.6%), and tetracycline (25/32; 78.1%) than for any of the other tested antibiotics. High levels of MDR (25/32; 78.1%) and the presence of ESBL (18/32; 56.2%) and AmpC (9/32; 28.1%) were observed in the DEC isolates. The isolates showed a higher frequency of the ESBL genes [ (18/18; 100%), (17/18; 94.4%)], and AmpC [ (4/9; 44.4%) and (4/9; 44.4%)] than of the other ESBL and AmpC genes.
Conclusion: Compared to the previous study, DEC appeared to be the second-most abundant agent of diarrhea in pediatric patients after , with frequent MDR and ESBL presence.
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| http://dx.doi.org/10.2147/IDR.S247732 | DOI Listing |
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