AI Article Synopsis
- Hypochlorous acid/hypochlorite (HOCl/OCl) is a key reactive oxygen species involved in various health processes, but abnormal levels are linked to diseases.
- The development of fluorescent probes for detecting HOCl/OCl is crucial, with numerous probes created over the past decade for in vitro and in vivo use.
- Despite advancements, challenges remain in creating specific and sensitive near-infrared (NIR) fluorescent probes for detecting endogenous OCl and for bioimaging at the subcellular level.
Article Abstract
Hypochlorous acid/hypochlorite (HOCl/OCl), as one of the most important reactive oxygen species (ROS), plays an important role in various physiological and pathological processes. Nonproperly located or abnormal concentration of OCl, however, is associated with many diseases. Thus, developing the fluorescent probe for detecting OCl is of great significance. To this end, in last decade, many fluorescent probes have been developed and applied for detecting HOCl/OCl in vitro and in vivo. Despite a great progress has achieved, the development and application of near-infrared fluorescent HOCl/OCl probe still have some challenges. For example, highly specific and sensitive NIR fluorescent HOCl/OCl probes applied in endogenous OCl detection and subcellular organelle bioimaging. In this review, we summarized the representative cases of HOCl/OCl probes with properties that mentioned above. The discussion contains design strategies, detection mechanisms, as well as applications in bioimaging.
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| http://dx.doi.org/10.1016/j.saa.2020.118545 | DOI Listing |
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