Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/01913123.2020.1778148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy.
J Thorac Oncol
April 2024
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon, associated with increased aging of populations worldwide. Although geoeconomic factors such as lack of regulations and continued asbestos manufacturing in resource-poor countries play a role, it is essential to consider biological factors such as immune senescence and increased genetic instability associated with aging.
View Article and Find Full Text PDFAsbestos and Iron.
Int J Mol Sci
August 2023
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Theories of disease pathogenesis following asbestos exposure have focused on the participation of iron. After exposure, an open network of negatively charged functional groups on the fiber surface complexes host metals with a preference for iron. Competition for iron between the host and the asbestos results in a functional metal deficiency.
View Article and Find Full Text PDFMechanisms and shapes of causal exposure-response functions for asbestos in mesotheliomas and lung cancers.
Environ Res
August 2023
University of Vermont Larner College of Medicine, Department of Pathology and Laboratory Medicine, USA.
This paper summarizes recent insights into causal biological mechanisms underlying the carcinogenicity of asbestos. It addresses their implications for the shapes of exposure-response curves and considers recent epidemiologic trends in malignant mesotheliomas (MMs) and lung fiber burden studies. Since the commercial amphiboles crocidolite and amosite pose the highest risk of MMs and contain high levels of iron, endogenous and exogenous pathways of iron injury and repair are discussed.
View Article and Find Full Text PDFMucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure.
Sci Rep
March 2023
Department of Pathology, Duke University Medical Center, Durham, NC, USA.
We tested the hypothesis that (1) mucus production can be included in the cell response to iron deficiency; (2) mucus binds iron and increases cell metal uptake; and subsequently (3) mucus impacts the inflammatory response to particle exposure. Using quantitative PCR, RNA for both MUC5B and MUC5AC in normal human bronchial epithelial (NHBE) cells decreased following exposures to ferric ammonium citrate (FAC). Incubation of mucus-containing material collected from the apical surface of NHBE cells grown at air-liquid interface (NHBE-MUC) and a commercially available mucin from porcine stomach (PORC-MUC) with iron demonstrated an in vitro capacity to bind metal.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!