Seven new modified fusicoccane-type diterpenoids (-), together with two known congeners ( and ), were obtained from . Their structures were elucidated from a combination of NMR and HRESIMS data and C NMR calculation as well as DP4+ probability analyses, and the absolute configurations of - were determined by ECD calculation and single-crystal X-ray diffraction (Cu Kα). Compounds - belong to a rare class of 16--dicyclopenta[]cyclooctane diterpenoids, and compounds and represent the first examples of fusicoccane-type diterpenoids featuring two previously undescribed tetracyclic 5/6/6/5 ring systems, while compound features a previously undescribed tetracyclic 5/8/5/3 ring system. Compound was moderately anti-inflammatory, and compounds , , , and were weakly cytotoxic.
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http://dx.doi.org/10.1021/acs.jnatprod.0c00165 | DOI Listing |
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