Modified Fusicoccane-Type Diterpenoids from .

J Nat Prod

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.

Published: June 2020

Seven new modified fusicoccane-type diterpenoids (-), together with two known congeners ( and ), were obtained from . Their structures were elucidated from a combination of NMR and HRESIMS data and C NMR calculation as well as DP4+ probability analyses, and the absolute configurations of - were determined by ECD calculation and single-crystal X-ray diffraction (Cu Kα). Compounds - belong to a rare class of 16--dicyclopenta[]cyclooctane diterpenoids, and compounds and represent the first examples of fusicoccane-type diterpenoids featuring two previously undescribed tetracyclic 5/6/6/5 ring systems, while compound features a previously undescribed tetracyclic 5/8/5/3 ring system. Compound was moderately anti-inflammatory, and compounds , , , and were weakly cytotoxic.

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http://dx.doi.org/10.1021/acs.jnatprod.0c00165DOI Listing

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