Hypolipidemic and anti-inflammatory properties of phenolic rich fruit extract: potential involvement of paraoxonase activity.

This study investigated the effects of polar fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol. Animals were divided into 3 groups: saline, saline plus tyloxapol, and extract plus tyloxapol. Animals were treated for 15 days with a saline solution or fruit extract and after hyperlipidaemia was induced by tyloxapol. Treatment with extract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher in extract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present in fruit extract were identified and quantified by LC-MS/MS. These findings indicated that phenolic rich extract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.