Needle-type organic electrochemical transistor for spatially resolved detection of dopamine.

Mikrochim Acta

Analytical Chemistry-Center for Electrochemical Sciences (CES), Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstraße 150, 44780, Bochum, Germany.

Published: June 2020

In this work, the advantages of carbon nanoelectrodes (CNEs) and orgonic electrochemical transistors (OECTs) were merged to realise nanometre-sized, spearhead OECTs based on single- and double-barrel CNEs functionalised with a conducting polymer film. The needle-type OECT shows a high aspect ratio that allows its precise positioning by means of a macroscopic handle and its size is compatible with single-cell analysis. The device was characterised with respect to its electrolyte-gated behaviour and was employed as electrochemical sensor for the proof-of-concept detection of dopamine (DA) over a wide concentration range (10-10 M). Upon application of fixed drain and gate voltages (V = - 0.3 V, V = - 0.9 V, respectively), the nano-sized needle-type OECT sensor exhibited a linear response in the low pM range and from 0.002 to 7 μM DA, with a detection limit of 1 × 10 M. Graphical abstract.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283208PMC
http://dx.doi.org/10.1007/s00604-020-04352-1DOI Listing

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