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Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives.
Biochemistry
December 2024
Institute of Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, Hannover 30167, Germany.
Farnesyl pyrophosphate derivatives bearing an additional oxygen atom at position 5 proved to be very suitable for expanding the substrate promiscuity of sesquiterpene synthases (STSs) and the formation of new oxygenated terpenoids. Insertion of an oxygen atom in position 9, however, caused larger restraints that led to restricted acceptance by STSs. In order to reduce some of the proposed restrictions, two FPP-ether derivatives with altered substitution pattern around the terminal olefinic double bond were designed.
View Article and Find Full Text PDFUGT708S6 from Dendrobium catenatum, catalyzes the formation of flavonoid C-glycosides.
BMC Biotechnol
November 2024
Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Background: Dendrobium catenatum is a perennial herb of the genus Dendrobium orchidaceae. It has been known as "Golden Grass, Soft Gold" since ancient times with effects of strengthening the body, benefiting the stomach, generating body fluid, nourishing Yin and clearing internal heat. The flowers of D.
View Article and Find Full Text PDFFrameshift Mutations in Genes Encoding PBP3 and PBP4 Trigger an Unusual, Extreme β-Lactam Resistance Phenotype in .
ACS Infect Dis
November 2024
Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio 44106, United States.
In our curated panel of complex isolates, strain AU28442 was unusually highly β-lactam resistant. To explore the molecular mechanisms leading to this phenotype, we performed whole genome sequencing (WGS) and microbiological and biochemical assays. WGS analysis revealed that strain AU28442 produced two β-lactamases, AmpC22 and a novel PenA-like β-lactamase denominated PenA39.
View Article and Find Full Text PDFAdaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies.
Nat Commun
October 2024
Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Promiscuous enzymes often serve as the starting point for the evolution of novel functions. Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several times independently for different purposes during evolution is poorly reported. Here, we present a case study illustrating how NAD(P)-dependent succinate semialdehyde dehydrogenase of Escherichia coli (Sad) is independently recruited through various evolutionary mechanisms for distinct metabolic demands, in particular vitamin biosynthesis and central carbon metabolism.
View Article and Find Full Text PDFDisruptions to protein kinase A localization in adrenal pathology.
Biochem Soc Trans
October 2024
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, U.S.A.
Article Synopsis
- - Cell signaling accuracy depends on specific interactions between proteins and the correct placement of signaling molecules within cells.
- - Many kinases and phosphatases can interact with various substrates, so they need precise targeting to ensure they only affect the right ones and prevent interference between different signaling pathways.
- - Recent research highlights how improper localization and interactions of the protein kinase A catalytic subunit (PKAc) contribute to conditions like cortisol-producing adenomas and adrenal Cushing's syndrome, and reviews both classic and recent studies on this topic.
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