AI Article Synopsis
- Ovarian cancer has a high mortality rate, and despite many patients responding well initially to treatment, 65-80% experience recurrence within five years, often indicating a poor prognosis, especially if recurrence occurs within six months after platinum-based chemotherapy.
- Current treatment for platinum-resistant ovarian cancer mainly involves single-agent chemotherapy, but other treatment options have not shown promising results.
- Although immunotherapy has shown potential in treating various solid tumors, there is currently not enough strong evidence to recommend its routine use for platinum-resistant ovarian cancer, suggesting a need for further research and strategies.
Article Abstract
Ovarian cancer is characterized by a high mortality on incidence ratio. Although the majority of patients achieve complete response after primary treatment, approximately 65-80% of patients recur with the first 5 years. Platinum-free interval is one of the main prognostic factors. Patients recurring with 6 months within the end of platinum-based chemotherapy are characterized by poor prognosis. To date no effective treatment modality are identified for those patients. The mainstay of treatment for platinum-resistant ovarian cancer is single agent chemotherapy. Other treatment modalities have tested in this setting with discouraging results. Growing evidence suggested that immunotherapy would improve outcomes of patients with various types of solid tumors including melanoma, non-small cell lung cancer as well as uterine malignancies. Here, we reviewed current evidence on the adoption of immunotherapy in platinum-resistant ovarian cancer. To date no mature evidence supports the routine adoption of immunotherapy in ovarian cancer patients. Further strategies have to be explored.
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| http://dx.doi.org/10.1016/j.ygyno.2020.05.681 | DOI Listing |
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