Decisions made by gait researchers in the generation of kinematic or musculoskeletal models are a potential source of variation between researchers, leading to variable model outcomes. Statistical shape models can accurately predict bone geometry and have the potential to improve the repeatability of clinical gait analysis. The purpose of this study was to determine if using a shape model to scale segment length and joint centre locations would improve repeatability of kinematic and kinetic gait data, compared to linear scaling methods. Five participants completed a motion capture experiment, including a standing static trial and walking at a self-selected speed. Anatomical landmarks from the static trial were used by five experienced researchers to generate kinematic models using two methods; (1) linear scaling in OpenSim, and (2) shape-model scaling using our 'MAP Client' scale tool. The resulting models were used to perform an inverse kinematic and inverse dynamic analysis on the walking trials, and variation between researchers was analysed by comparing outputs from the same motion capture trial using different models. Higher variability between researchers was observed in joint angles (P < 0.001), joint moments (P < 0.005), and joint powers (P < 0.005) when using linear scaling, compared to shape-model scaling. Variation was at least three times as large for linearly-scaled models compared to shape-model scaled models. We have identified that linear scaling can lead to substantial variability in gait data across researchers, even with the same experimental data. Using a shape model to scale musculoskeletal models results in repeatable kinematic and kinetic gait data.
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http://dx.doi.org/10.1016/j.jbiomech.2020.109838 | DOI Listing |
Dokl Biochem Biophys
January 2025
Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia.
The study presents a numerical parametric investigation of flow structures in channels with a longitudinal-radial profile zR = Const and a spherical dome at the base. The goal of the study was to examine the flow structures in these channels depending on the exponent N of the profile and the height of the dome, to determine the conditions that provide optimal centripetal swirling flow, analogous to blood flow in the heart chambers and major vessels. The investigation was conducted using a comparative analysis of flow structures in channel configurations zR = Const, carried out in two stages.
View Article and Find Full Text PDFBull Math Biol
January 2025
Department of Mathematics, Vivekananda College, Kolkata, West Bengal, 700063, India.
The extinction of species is a major threat to the biodiversity. Allee effects are strongly linked to population extinction vulnerability. Emerging ecological evidence from numerous ecosystems reveals that the Allee effect, which is brought on by two or more processes, can work on a single species concurrently.
View Article and Find Full Text PDFJ Vasc Surg
January 2025
Nephrology Division, University of Washington, Seattle, WA; Providence Medical Research Center, Providence Inland Northwest Health, Spokane, WA.
Background: Chronic limb-threatening ischemia (CLTI) in patients with chronic kidney disease (CKD) has a high risk of poor outcomes. We aimed to compare the outcomes of lower extremity revascularization in patients with CLTI stratified by CKD severity in patients enrolled in the prospective, randomized Best Endovascular vs Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial.
Methods: The BEST-CLI trial dataset was queried to categorize patients into three groups according to CKD stage.
Microbiol Spectr
January 2025
Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, Northeast Normal University, Changchun, China.
Animal skin acts as the barrier against invasion by pathogens and microbial colonizers. Environmental microbiota plays a significant role in shaping these microbial communities, which, in turn, have profound implications for host health. Previous research has focused on characterizing microorganisms on bats' skin and in their roosting environments, particularly bacterial communities.
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