AI Article Synopsis
- MRI is a key noninvasive method for detecting and staging cancer, utilizing contrast agents to distinguish between healthy and tumor tissues.
- Gd-loaded gold nanoparticles are a new type of MRI contrast agent, where their size, shape, and chemical properties influence their effectiveness.
- Research shows that concave cube gold nanoparticles provide significantly higher relaxation enhancement than spherical ones, primarily due to their interaction with water molecules around them, which could improve the design of more efficient MRI contrast agents.
Article Abstract
Nowadays, magnetic resonance imaging (MRI) is one of the key, noninvasive modalities to detect and stage cancer which benefits from contrast agents (CA) to differentiate healthy from tumor tissue. An innovative class of MRI CAs is represented by Gd-loaded gold nanoparticles. The size, shape and chemical functionalization of Gd-loaded gold nanoparticles appear to affect the observed relaxation enhancement of water protons in their suspensions. The herein reported results shed more light on the determinants of the relaxation enhancement brought by Gd-loaded concave cube gold nanoparticles (CCGNPs). It has been found that, in the case of nanoparticles endowed with concave surfaces, the relaxivity is remarkably higher compared to the corresponding spherical (i.e., convex) gold nanoparticles (SPhGNPs). The main determinant for the observed relaxation enhancement is represented by the occurrence of a large contribution from second sphere water molecules which can be exploited in the design of high-efficiency MRI CA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353348 | PMC |
| http://dx.doi.org/10.3390/nano10061115 | DOI Listing |
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