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Lymphocytic Esophagitis Associated With Chronic Severe Psoriasis: A Case Report With Special Reference to Programmed Death-Ligand 1 Expression.
Cureus
October 2024
Department of Pathology, Jossigny Hospital, Jossigny, FRA.
Lymphocytic esophagitis (LE) is a rare type of chronic esophagitis, marked by an increased number of peripapillary intraepithelial lymphocytes (IEL) with little to no presence of intraepithelial granulocytes and intercellular edema. There is currently no established standard for quantifying IEL in the esophageal mucosa. Clinically, LE manifests with a range of symptoms, including difficulty swallowing (dysphagia), indigestion (dyspepsia), nausea, and chest pain.
View Article and Find Full Text PDFBrepocitinib, a potent and selective TYK2/JAK1 inhibitor: scientific and clinical rationale for dermatomyositis.
Clin Exp Rheumatol
July 2024
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Dermatomyositis (DM) is a rare and debilitating, systemic, autoimmune disease. While heterogenous in presentation and severity, DM is primarily characterised by a spectrum of skin and muscle disease, which may include proximal muscle weakness and recalcitrant cutaneous eruptions. DM may also be associated with joint pain and stiffness, inflammatory arthritis, dysphagia, fatigue, and calcinosis.
View Article and Find Full Text PDFImmunobullous Transformation of Protracted Psoriasis: A Diagnostic Dilemma.
Cureus
April 2023
Histopathology, St Thomas' Hospital, London, GBR.
Pemphigus vulgaris is a rare autoimmune disorder, characterised by the development of blistering lesions in the skin and mucosal surfaces throughout the body. It is often misdiagnosed or missed completely in many patients, prolonging their suffering for many years, as it has the ability to mimic an array of other skin diseases. Many studies have concluded that there is a strong association between pemphigus vulgaris and psoriasis, though the exact mechanism is not clearly understood.
View Article and Find Full Text PDFDiffuse idiopathic skeletal hyperostosis as a cause for dysphagia in a patient with ankylosing spondylitis.
Wien Klin Wochenschr
June 2023
Department for Internal Medicine IV, Klinik Ottakring, Montleartstr. 37, 1160, Vienna, Austria.
Background: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ankylosing spinal alterations which are often asymptomatic but may typically cause back pain and spinal stiffness. Presence of DISH may complicate spinal trauma and lead to unstable fractures requiring surgical intervention. Treatment options include physical activity, symptomatic treatment, local heat application, and optimization of metabolic comorbidities.
View Article and Find Full Text PDFCase of systemic sclerosis overlapping with psoriasis.
Int J Rheum Dis
June 2023
Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, China.
Coexistence of the skin manifestations of systemic sclerosis and psoriasis is rare. The link between systemic sclerosis and psoriasis has been poorly investigated. We report a case of a 70-year-old woman, who was diagnosed with diffuse cutaneous systemic sclerosis and psoriasis vulgaris and was treated with oral azathioprine (50 mg/d) and prednisolone (10 mg/d), topical corticosteroids, and calcipotriols.
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