Across vertebrates, eye movements serve the dual purpose of image stabilization during head or body movement, and gaze relocation. A new study has measured head and bilateral eye movements in freely moving mice, providing a detailed characterization of dynamic gaze behavior.
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http://dx.doi.org/10.1016/j.cub.2020.04.063 | DOI Listing |
Alzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Phenotyping Alzheimer's Disease (AD) can be crucial to providing personalized treatment. Several studies have analyzed the use of digital biomarkers to characterize a subject's behavior, usually obtained from a single modality, such as speech. However, combining several modalities in a single study has not been deeply studied.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Clinical rating scales and neuropsychological tests are commonly used for assessing sign and disease severity, yet lack detail in the early stages Alzheimer's Disease (AD). Existing evaluation methods can be subjective, nonlinear, expensive, or reliant on anecdotal evidence making objective and consistent characterization and phenotyping of AD difficult. Multimodal analysis of patient behavior, rather than scoring of patient-generated output which can be skewed by compensation strategies, presents a unique opportunity to objectively quantify AD related changes.
View Article and Find Full Text PDFCureus
January 2025
Department of Ophthalmology, Leeds Teaching Hospitals NHS Trust, Leeds, GBR.
Chronic progressive external ophthalmoplegia (CPEO) is a rare mitochondrial disorder characterized by bilateral, slowly progressive ptosis and paralysis of the extraocular muscles. We present the case of a 61-year-old female with a 36-year history of bilateral ptosis and limited eye movements without diplopia. No family history of CPEO or other mitochondrial disorders was reported.
View Article and Find Full Text PDFBiomed Eng Lett
January 2025
Biomedical Imaging, Vision and Learning Laboratory(BivL2ab), Universidad Industrial de Santander (UIS), Bucaramanga, 680002 Santander Colombia.
Parkinson's disease is a neurodegenerative disorder principally manifested as motor disabilities. In clinical practice, diagnostic rating scales are available for broadly measuring, classifying, and characterizing the disease progression. Nonetheless, these scales depend on the specialist's expertise, introducing a high degree of subjectivity.
View Article and Find Full Text PDFVision Res
January 2025
Center for Psychological Science, Zhejiang University, Hangzhou, China.
Prior research has established that actions, such as eye movements, influence time perception. However, the relationship between pre-saccadic attention, which is often associated with eye movement, and subjective time perception is not explored. Our study examines the impact of pre-saccadic attention on the subjective experience of time during eye movements, particularly focusing on its influence on subjective time perception at the saccade target.
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