The developing nanoparticle therapeutic agents triggered by tumor microenvironment are a feasible strategy for the substantial elevation of accuracy of diagnosis and the reduction of side effects in cancer treatments. Dysregulated HS production from the enzyme system of overexpressed cystathionine β-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer. Herein, for the first time, an endogenous HS-activated copper metal-organic framework (Cu-MOF; HKUST-1) nanoenzyme has been demonstrated to synergistically mediate HS-activated near-infrared photothermal therapy and chemodynamic therapy in the effective treatment of colon cancer. This endogenous biomarker-triggered "turn-on" strategy to generate therapeutic agents could largely simplify the constitution of nanomedicine by avoiding the cargo introduction and thus supply great promise for the precise treatments of colon cancer.
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| http://dx.doi.org/10.1021/acsami.0c08659 | DOI Listing |
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