AI Article Synopsis

  • - The review discusses the link between periodontal inflammation and oral bacteria in the development of atherosclerosis and cardiovascular diseases, emphasizing that this relationship is still being explored.
  • - While a connection between periodontal disease and cardiovascular issues is recognized, causal relationships haven't been definitively proven, and untreated gingivitis can escalate to more severe forms.
  • - Improving oral health if there's periodontal disease may help reduce overall body inflammation and potentially prevent cardiovascular diseases, though more research is necessary to confirm these effects.

Article Abstract

Purpose Of Review: The role of oral bacteremia and periodontal inflammation driving atherosclerosis is still under investigation. This review article highlights the role of periodontal inflammation and oral microorganisms in the development and progression of atherosclerosis and cardiovascular diseases.

Recent Findings: Association between periodontal and cardiovascular diseases has been well characterized, but causal correlation is yet to be established. For instance, untreated gingivitis can progress to periodontitis. Periodontal disease has been associated with several systemic diseases one of which is atherosclerosis. One possible association that was documented in literature is that poor oral hygiene leads to bacteremia, which in turn can cause bacterial growth over atherosclerotic coronary artery plaques and possibly worsen coronary artery disease. It is crucial that clinicians understand the association between periodontal and cardiovascular disease. A comprehensive treatment for periodontitis and re-establishment of a healthy periodontium can help in reduction of overall inflammation in the body. This may play an important role in prevention of cardiovascular disease, though future research is needed to establish this.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11883-020-00848-6DOI Listing

Publication Analysis

Top Keywords

periodontal inflammation
12
cardiovascular disease
12
association periodontal
8
periodontal cardiovascular
8
coronary artery
8
periodontal
6
cardiovascular
5
disease
5
inflammation risk
4
risk cardiovascular
4

Similar Publications

Periodontal disease stands the leading cause of tooth loss in adults. While scaling and root planning is considered the "gold standard" treatment, it is often insufficient in efficiently eliminating anaerobic bacteria from deep periodontal pockets. In this work, an antibiotic-free and photo-curing hyaluronic acid-Janus (H-Janus) antibacterial pack was developed to inhibit the growth and colonization of residual bacteria within the pockets for reducing the recurrence of periodontitis.

View Article and Find Full Text PDF

Osteoarthritis (OA) is a joint disease characterized by articular cartilage degradation. Persistent low-grade inflammation defines OA pathogenesis, with crucial involvement of pro-inflammatory M1-like macrophages. While mesenchymal stromal cells (MSC) and their small extracellular vesicles (sEV) hold promise for OA treatment, achieving consistent clinical-grade sEV products remains a significant challenge.

View Article and Find Full Text PDF

Serum Nutrients, Periodontitis and Biological Ageing.

J Clin Periodontol

January 2025

Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.

Introduction: Telomeres are nucleotide sequences found at the end of chromosomes, and their shortening is associated with chronological and biological ageing, oxidative stress and malnutrition. Shorter telomeres have been shown to be associated with periodontitis. Dietary nutrients are also influential factors in the aetiology and progression of periodontitis and other chronic inflammatory diseases.

View Article and Find Full Text PDF

Background: Intracranial aneurysms (IAs) are a significant clinical concern, with detection rates increasing due to advances in imaging technologies. However, precise mechanisms underlying their pathophysiology remain incompletely understood. Recent evidence suggests a pivotal role of oral microbiota dysbiosis, particularly periodontal pathogens, in systemic inflammation that may contribute to IA development and rupture.

View Article and Find Full Text PDF

Aims: Circular RNA forkhead box O3 (circFOXO3) is crucial in regulating inflammation in lung and heart injuries. However, its role in periodontitis remains unclear. We sought to elucidate the effects of circFOXO3 on periodontitis progression and related molecular mechanisms.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!