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Adalimumab-Induced Erythrodermic Psoriasis Associated with Alopecia in a Patient with Palmoplantar Pustulosis.
Indian J Dermatol
April 2024
From the Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Article Synopsis
- Increased use of TNF inhibitors has led to the discovery of more side effects, particularly paradoxical psoriasis.
- Paradoxical psoriasis can manifest in various forms, including psoriasis vulgaris and scalp psoriasis.
- A case is reported of a 44-year-old woman who developed rare erythrodermic psoriasis and alopecia while being treated with adalimumab for palmoplantar pustulosis.
Adalimumab-Induced Psoriasis with Severe Alopecia.
Skinmed
May 2022
Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon;
Article Synopsis
- A 52-year-old woman with a history of Crohn's disease and arthritis experienced severe hair loss after starting treatment with adalimumab.
- She developed pustular lesions on her palms, soles, and scalp, leading to the discontinuation of adalimumab and a switch to ustekinumab injections.
- After two months of ustekinumab, she sought treatment at a dermatology clinic for her ongoing alopecia, noting she had no personal or family history of psoriasis.
Adalimumab-induced scalp psoriasis with severe alopecia as a paradoxical effect in a patient with Crohn's disease successfully treated with ustekinumab.
Dermatol Ther
July 2020
Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece.
Adalimumab-induced scalp psoriasis with severe alopecia.
Dermatol Ther
September 2019
Department of Dermatology, University of Health Sciences, Şişli Etfal Training and Research Hospital, İstanbul, Turkey.
In recent years, with the increase usage of tumor necrosis factor (TNF) inhibitors, more side effects have revealed. The incidence of paradoxical psoriasis (psoriasis vulgaris, palmoplantar pustulosis, scalp psoriasis, or their combinations) ranges from 1 to 5%; however alopecia due to anti-TNF-α-induced scalp psoriasis, rarely reported in the literature. We report a 37-year-old woman who developed palmoplantar pustulosis and scalp psoriasis with severe alopecia after 2 months of treatment with adalimumab for chronic plaque psoriasis.
View Article and Find Full Text PDFDevelopment of two primary malignant melanomas after treatment with adalimumab: a case report and review of the possible link between biological therapy with TNF-alpha antagonists and melanocytic proliferation.
Dermatology
August 2010
2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, School of Medicine, Attikon General University Hospital, Athens, Greece.
Biologics, such as tumor necrosis factor alpha (TNF-alpha) antagonists, have revolutionized treatment of several significant inflammatory autoimmune diseases. Nevertheless, issues concerning long-term safety remain to be clarified. There is growing evidence linking biological treatments with the occurrence of malignancies or reactivation of latent ones, including malignant melanoma.
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