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| http://dx.doi.org/10.1111/all.14435 | DOI Listing |
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Diagnostic potential of rhinovirus C using reverse-transcription loop-mediated isothermal amplification (RT-LAMP).
Int Microbiol
December 2024
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Rhinoviruses (RVs), particularly RV-C, frequently cause acute respiratory infections and asthma exacerbations. However, there is a lack of routine detection methods. Thus, this study aims to develop a rapid molecular and differential diagnostic detection method for RV-C using the reverse transcription (RT) loop-mediated isothermal amplification (LAMP) approach.
View Article and Find Full Text PDFSurfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma.
Viruses
October 2024
Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critical role in regulating pulmonary innate immunity by binding to numerous respiratory pathogens. Mature SP-A consists of multiple isoforms that form the hetero-oligomers of SP-A1 and SP-A2, organized in 18-mers.
View Article and Find Full Text PDFAssociation between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults.
J Allergy Clin Immunol Glob
February 2025
Université Grenoble Alpes, INSERM U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.
Background: Viral infections in childhood, especially to rhinovirus (RV) and respiratory syncytial virus (RSV), are associated with asthma inception and exacerbation. However, little is known about the role of RV- and RSV-specific antibodies in childhood versus adult asthma.
Objective: We sought to investigate associations between RV- and RSV-specific IgG levels and asthma phenotypes in children and adults.
The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.
J Allergy Clin Immunol
October 2024
Department of Otolaryngology, University of Arizona, Tucson, Ariz; Asthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz. Electronic address:
Article Synopsis
- Acute exacerbations of chronic rhinosinusitis (AECRS) are often worsened by rhinovirus (RV) infections, and the study investigates genetic risk factors associated with these infections, focusing on the CDHR3 gene.
- In a year-long study, individuals carrying the minor allele rs6967330 showed significantly higher rates of RV and bacterial infections compared to those with the major allele.
- The study also found that nasal airway cultures from minor allele carriers had higher levels of viral replication and exhibited changes in immune response pathways, suggesting that these genetic factors affect how the body responds to RV infections.
Viral Determinants of Childhood Asthma Exacerbation Severity and Treatment Response.
J Allergy Clin Immunol Pract
January 2025
Center for Genes, Environment and Health, National Jewish Health, Denver, Colo; Department of Pediatrics, National Jewish Health, Denver, Colo; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colo.
Article Synopsis
- The study investigates how different respiratory viruses affect asthma exacerbations in children aged 4 to 18 who seek treatment in the emergency department (ED).
- Results showed that 86% of children tested positive for viruses, with rhinovirus A leading to milder symptoms and better treatment responses, while enterovirus D68 was linked to more severe cases and poor treatment outcomes.
- The findings suggest that identifying the specific virus early could improve management and outcomes for pediatric asthma exacerbations.
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