Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2257.1988.tb01198.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pleural Rosai-Dorfman disease complicated with renal clear cell carcinoma: a case report and literature review.
Front Oncol
January 2025
Department of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Background: Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare non-malignant disorder characterized by excessive proliferation of histiocytes, the cause of which remains unknown. Although the lymph nodes are the most commonly affected site, some patients may present with extranodal involvement, particularly in the skin, nasal cavity, eyes, and bones. In this report, we aim to present a unique case of RDD with pleural involvement in a 61-year-old patient.
View Article and Find Full Text PDFRenal Immune-Related Adverse Event Difficult to Diagnose during Nivolumab Treatment for Hypopharyngeal Carcinoma: Case Report.
Case Rep Oncol
August 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku Ward, Tokyo, Japan.
Article Synopsis
- Nivolumab, an immunotherapy drug, can cause immune-related adverse events (irAEs) affecting various organs, though renal complications are less common and can be challenging to diagnose.
- A case study of a 65-year-old man with hypopharyngeal carcinoma revealed renal dysfunction and pyuria after nivolumab treatment, which initially led to confusion regarding the diagnosis of a renal irAE due to only mild creatinine elevation.
- The study emphasizes the importance of considering renal irAEs in patients with abnormal urinalysis and renal dysfunction, as missed diagnoses can occur when renal biopsies are not performed.
Comprehensive population pharmacokinetic modelling of sugemalimab, an anti-programmed death-ligand 1 (PD-L1) human monoclonal antibody, in patients with solid tumours or lymphomas across multiple Phase I-III studies.
Br J Clin Pharmacol
October 2024
Cstone Pharmaceuticals (Suzhou) Co., Ltd., Shanghai, China.
Article Synopsis
- The study aimed to create a population pharmacokinetics (PopPK) model for sugemalimab, a PD-L1 targeting monoclonal antibody, using data from multiple clinical trials to understand factors affecting drug exposure.
- A nonlinear mixed-effect modelling approach analyzed data from 1628 subjects across nine studies, assessing how different characteristics like demographics and health conditions impacted sugemalimab pharmacokinetics.
- The final model showed that body weight, albumin, gender, and tumor characteristics significantly influenced drug clearance, though none of these covariates had a clinically meaningful effect on overall sugemalimab exposure, suggesting no need for dose adjustments based on these factors.
A Curious Case of Pericardial Effusion Diagnosed as Diffuse Large B-cell Lymphoma.
Cureus
August 2024
General Medicine, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Pune, IND.
Lymphoma arises from mature B, T, and natural killer (NK) cells. Lymphomas are classified into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is a type of NHL.
View Article and Find Full Text PDFUnusual presentation in a case of diffuse large B-cell lymphoma.
Radiol Case Rep
October 2024
Department of Hematology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Non-Hodgkin's lymphoma are neoplasms derived from T cells and B cells and their precursors in the lymphoid system with higher susceptibility in involvement of extra-nodal sites. Predominant ureteric involvement is an unusual presentation. We present a case of diffuse large B-cell lymphoma with secondary involvement of ureter who had symptoms of urinary tract infection in absence of positive urine culture, non-responsive to broad spectrum antibiotics and masquerading pyogenic infection leading to pyelonephritis with ureteritis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!