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Predictive signatures of immune response to vaccination and implications of the immune setpoint remodeling.
mSphere
January 2025
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
In 2020, I featured two articles in the "mSphere of Influence" commentary series that had profound implications for the field of immunology and helped shape my research perspective. These articles were "Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses" by Tsang et al. (Cell 157:499-513, 2014, https://doi.
View Article and Find Full Text PDFMolecular Imaging of Paragangliomas and Pheochromocytomas.
Radiol Imaging Cancer
January 2025
From the Department of Radiology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905.
Distinct roles of mTORC2 in excitatory and inhibitory neurons in inflammatory and neuropathic pain.
Brain
January 2025
Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Hunting for heroes: Brain neurons mediating GLP-1R agonists in obesity treatment.
Obes Med
December 2024
The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, MD Anderson Cancer Center & UTHealth Houston Graduate School for Biomedical Sciences, University of Texas Health Science at Houston, Texas, 77030, USA.
Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs) have proven to be highly effective in reducing obesity across species and ages, gaining unmet popularity in clinical treatments against obesity. Although extensive research efforts have been made to explore how the brain regulates body weight homeostasis including the effect brought up by GLP-1 and its synthetic analogs GLP-1RAs, the identity of neurons and neural pathways that are responsible for the observed anti-obesity effect of GLP-1RAs remain largely elusive. Excitingly, three recent high-profile studies presented compelling evidence that each argues for the importance of GLP-1Rs in the dorsomedial hypothalamus, hindbrain, or lateral septum, respectively, in mediating the anti-obesity effect of GLP-1RAs.
View Article and Find Full Text PDFBridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances.
Mol Cell
January 2025
Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. Electronic address:
By building synthetic regulatory landscapes, Jensen et al. and Thomas et al. demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.
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