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Video-oculography for enhancing the diagnostic accuracy of early oculomotor dysfunction in Progressive Supranuclear Palsy.
J Mov Disord
December 2024
Parkinson and Movement Disorder Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.
Background: Oculomotor impairment is an important diagnostic feature of Progressive Supranuclear Palsy (PSP) and PSP subtypes.
Objectives: We assessed the role of video oculography (VOG) in confirming clinically suspected slow saccades in PSP and differentiating PSP from Parkinson's disease (PD). We also measured the correlation of both saccadic velocity and latency in PSP with scores in PSP rating scale, Montreal Cognitive Assessment (MoCA) and Frontal assessment battery (FAB).
Acquired double depressor palsy following bilateral medial thalamus and left midbrain infarction.
J AAPOS
December 2024
Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Universal Eye Center, Taipei, Taiwan. Electronic address:
We present the case of a 57-year-old man with vertical diplopia who was diagnosed with acquired left eye supranuclear double depressor palsy after ischemic stroke, with small infarcts at the bilateral medial posterior thalami, left midbrain, and left occipital lobe. Given the different innervation of the two depressors, intact vestibulo-ocular reflex, and the healthy inferior rectus muscle morphology observed intraoperatively, the lesion likely involved the supranuclear vertical gaze center or its pathway. His strabismus was treated successfully with recession and resection of vertical rectus muscles, resulting in no significant deviation in either the vertical or horizontal directions in primary gaze at 6 months' follow-up.
View Article and Find Full Text PDFVertical one-and-a-half syndrome with horizontal internuclear ophthalmoplegia and bilateral supranuclear ptosis in rostral midbrain and medial thalamic stroke.
BMJ Case Rep
October 2024
Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, People's Republic of China.
Introduction: Gaucher disease type 3 (GD3) is a genetic, progressive lysosomal storage disorder characterized by visceral manifestations and chronic neurologic symptoms (e.g., horizontal ophthalmoplegia/supranuclear gaze palsy, ataxia, dystonia).
View Article and Find Full Text PDFAnti-IgLON5 disease as a differential diagnosis of multiple system atrophy.
Parkinsonism Relat Disord
July 2024
Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address:
Article Synopsis
- - Anti-IgLON5 disease is a rare autoimmune condition that can mimic symptoms of various neurodegenerative disorders, notably progressive supranuclear palsy and multiple system atrophy (MSA).
- - In a study of 35 patients suspected of having MSA, anti-IgLON5 antibodies were found in three individuals who exhibited similar clinical features, such as parkinsonism and severe orthostatic hypotension, along with some atypical symptoms.
- - The research suggests that anti-IgLON5 disease should be considered when diagnosing MSA, emphasizing the need for thorough physical examinations to differentiate between these conditions effectively.
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