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T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats. | LitMetric

T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats.

Behav Brain Res

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.

Published: September 2020

AI Article Synopsis

  • Z944, a T-type calcium channel blocker, has been studied for its potential as an anti-epileptic and its effects on fear learning and memory in rodents.
  • In male Wistar rats, Z944 treatment resulted in increased freezing behavior during fear conditioning, affecting learning and recall negatively 24 hours later.
  • The study raises concerns about the impact of Z944 on anxiety and memory, suggesting it should be carefully evaluated for therapeutic use in clinical settings.

Article Abstract

The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory in a non-disease outbred rodent strain. This study examined the dose-dependent effects (5 mg/kg, 10 mg/kg, i.p.) of acute systemic treatment with Z944 on the learning and memory of fear conditioning and extinction in male Wistar rats. Z944 administered prior to the acquisition of fear conditioning significantly increased freezing prior to acquisition and extinction, during acquisition, and impaired recall of fear memory 24 h later. These findings suggest that T-type calcium channel activity may be required during associative learning for intact long-term memory. Enhanced fear behaviour observed prior to acquisition and extinction, and during acquisition could reflect an increase in anxiety, however, further testing is needed to determine the effect of Z944 on anxiety during fear conditioning and extinction. The use of Z944 for therapeutic purposes should consider the potential effects of Z944 on learning and memory in clinical populations.

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Source
http://dx.doi.org/10.1016/j.bbr.2020.112747DOI Listing

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