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Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis. | LitMetric

AI Article Synopsis

  • - Stereotactic Radiosurgery is now the primary treatment for patients with a few brain metastases, but there's been an increase in cases of recurrence, which can be due to either tumor regrowth or radiation necrosis.
  • - Laser Interstitial Thermal Therapy (LITT) is introduced as a minimally invasive option for treating both primary and metastatic brain tumors, utilizing MRI for precise control over the treatment area.
  • - The study highlights LITT as a safe and effective technique for managing recurrent brain metastases, particularly beneficial for patients with hard-to-reach lesions where surgery isn’t feasible.

Article Abstract

Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Laser Interstitial Thermal Therapy (LITT) is minimally invasive treatment modality that has been used to treat primary and metastatic brain tumors. When associated with real-time thermometry using Magnetic Resonance Imaging, the extent of ablation can be controlled to provide maximum coverage and avoid eloquent areas. The objective of this study was to investigate the use of LITT in the treatment of BM. An extensive review of the relevant literature was conducted and the outcome results are discussed. There is an emphasis on safety and local control rate of patients treated with this modality. The findings of our study suggest that LITT is a viable safe technique to treat recurrent BM, especially in patients with deep-seated lesions where surgical resection is not an option.

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Source
http://dx.doi.org/10.1016/j.canlet.2020.05.014DOI Listing

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