Manganese exposure caused reproductive toxicity of male mice involving activation of GnRH secretion in the hypothalamus by prostaglandin E2 receptors EP1 and EP2.

Ecotoxicol Environ Saf

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China. Electronic address:

Published: September 2020

Exposure to manganese (Mn) can cause male reproductive damage and lead to abnormal secretion of sex hormones. Gonadotropin-releasing hormone (GnRH) plays an important role in the neuromodulation of vertebrate reproduction. Astrocytes can indirectly regulate the secretion of GnRH by binding paracrine prostaglandin E (PGE) specifically to the EP1 and EP2 receptors on GnRH neurons. Prior studies assessed the abnormal secretion of GnRH caused by Mn exposure, but the specific mechanism has not been reported in detail. This study investigated the effects of Mn exposure on the reproductive system of male mice to clarify the role of PGE in the abnormal secretion of GnRH in the hypothalamus caused by exposure to Mn. Our data demonstrate that antagonizing the EP1 and EP2 receptors of PGE can restore abnormal levels of GnRH caused by Mn exposure. Mn exposure causes reduced sperm count and sperm shape deformities. These findings suggest that EP1 and EP2, the receptors of PGE, may be the key to abnormal GnRH secretion caused by Mn exposure. Antagonizing the PGE receptors may reduce reproductive damage caused by Mn exposure.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110712DOI Listing

Publication Analysis

Top Keywords

caused exposure
20
ep1 ep2
16
abnormal secretion
12
secretion gnrh
12
ep2 receptors
12
male mice
8
gnrh
8
gnrh secretion
8
exposure
8
reproductive damage
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!