AI Article Synopsis
- miRNAs are non-coding RNAs that regulate gene expression after transcription and are key in processes like cell proliferation and invasion.
- miR-139-5p, found on chromosome 11q13.4, has been closely studied in relation to various cancers, showing potential as a cancer biomarker.
- This review will cover miR-139-5p's role in cancer diagnosis, prognosis, therapy, and its interactions with target genes and signaling pathways.
Article Abstract
miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either promote or suppress tumor development by mediating different signaling pathways. miR-139-5p, located on chromosome 11q13.4, has been examined extensively in cancers. Studies have demonstrated that miR-139-5p might be an attractive cancer biomarker. Herein, we will review how miR-139-5p acts in cancer diagnosis, prognosis, and therapy, as well as elucidating its major target genes and associated signaling pathways.
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| http://dx.doi.org/10.1016/j.lfs.2020.117865 | DOI Listing |
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