AI Article Synopsis
- Previous research found that Enterococcus faecalis 2001 (EF-2001) helps reduce depression-like symptoms caused by colitis by boosting neurogenesis in the hippocampus of mice.
- In the current study, EF-2001 was tested on mice with olfactory bulbectomy (OBX), showing significant improvement in cognitive function and counteracting the cognitive deficits caused by OBX.
- The findings suggest that EF-2001's potential to combat dementia may be linked to its ability to enhance neurogenesis in the hippocampus through the ERK-CREB-BDNF signaling pathway.
Article Abstract
Our previous study showed that Enterococcus faecalis 2001 (EF-2001) suppresses colitis-induced depressive-like behavior through the enhancement of hippocampal neurogenesis in mice. In the present study, we investigated the effect of EF-2001 on the cognitive behavior of olfactory bulbectomized (OBX) mice and its molecular mechanisms. The OBX-induced cognitive dysfunction was significantly suppressed by EF-2001. Moreover, EF-2001 also recovered the reductions in p-ERK1/2, p-CREB, BDNF and DCX levels and in neurogenesis observed in the hippocampus of OBX mice. These results suggest that EF-2001-induced antidementia effects are associated with enhanced hippocampal neurogenesis through the ERK-CREB-BDNF pathway.
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| http://dx.doi.org/10.1016/j.physbeh.2020.112997 | DOI Listing |
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