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Alzheimer's disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study.
Hereditas
January 2025
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, China.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains unclear.
Methods: A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD.
Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudi-nal Study.
Acta Derm Venereol
January 2025
Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel.
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.
View Article and Find Full Text PDFEarly diagnosis and treatment of Ramsay Hunt syndrome: a case report.
Int J Emerg Med
January 2025
Emergency Department, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Background: Ramsay Hunt syndrome (RHS), a rare complication of varicella-zoster virus (VZV) reactivation, presents with ipsilateral facial paralysis, ear pain, and vesicular rash. Early recognition is crucial for prompt treatment and optimal outcomes.
Case Presentation: We report a case of a 67-year-old woman with RHS who presented with right-sided facial palsy, severe ear pain, and fluid-filled blisters.
Cerebral Hemorrhage in Varicella-Zoster Virus Encephalitis: A Case Study.
Am J Case Rep
January 2025
Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BACKGROUND Varicella-zoster virus (VZV) encephalitis is a commonly reported form of encephalitis that clinically manifests as skin lesions, fever, headache, and neuropsychiatric symptoms. We present a case of a patient with VZV encephalitis complicated by cerebral hemorrhagic transformation, characterized by high levels of inflammation and protein in the cerebrospinal fluid. The aim is to highlight the risk of hemorrhagic transformation associated with VZV encephalitis.
View Article and Find Full Text PDFCerebral cavernous malformation with associated Streptococcus pyogenes abscess in a child: a case report and literature review.
Childs Nerv Syst
December 2024
Department of Neurosurgery, Sheffield Children's Hospital, Sheffield, UK.
Cerebral cavernous malformations (CCMs) are angiographically occult vascular lesions that present with a variety of neurological symptoms, including seizures, features of raised intracranial pressure and focal neurological deficits. In extremely rare circumstances, CCMs have presented with concomitant brain abscess formation. To date, five cases have previously been reported, the majority of which have affected patients aged 16 years or older.
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