AI Article Synopsis
- Researchers developed new chemical probes that combine a special warhead targeting serine hydrolases and pomalidomide, a drug that binds to cereblon.
- They used quantitative proteomics to study the effects of these probes on protein degradation.
- Although around 40 serine hydrolases were targeted, the only one successfully degraded was lysophospholipase II (LYPLA2).
Article Abstract
Novel chemical biology probes linking a serine hydrolase-directed fluorophosphonate warhead and cereblon-binding pomalidomide were assessed for the degradation of serine hydrolases. A quantitative proteomics approach to detect degraded proteins revealed that, despite the engagement of ∼40 serine hydrolases, degradation was achieved for only a single serine hydrolase, lysophospholipase II (LYPLA2).
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| http://dx.doi.org/10.1002/cbic.202000253 | DOI Listing |
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