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Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review.
Mediastinum
December 2024
Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA, USA.
Background And Objective: Diagnosis of pathology in the mediastinum has proven quite challenging, given the wide variability of both benign and malignant diseases that affect a diverse array of structures. This complexity has led to the development of many different non-invasive and invasive diagnostic modalities. Historically, diagnosis of the mediastinum has relied on different imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission topography.
View Article and Find Full Text PDFNew Instant Digital Pathology for EUS/EBUS Samples: The Last Advance in Bedside Diagnostics for Lung Carcinoma.
Cancers (Basel)
November 2024
Unit of Endocrine Organs and Neuromuscular Pathology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
Article Synopsis
- - Ex vivo fluorescence laser scanning microscopy (FCM) enables real-time imaging of fresh tissue samples without traditional slide preparation, and this study specifically investigates its application in evaluating biopsy samples from endoscopic procedures for lung lesions and lymph nodes.
- - The study involved 32 patients, showing that the FCM Vivascope 2500 could accurately assess sample adequacy and malignancy, with a perfect agreement noted between its evaluations and final histological results.
- - The findings suggest that FCM could significantly improve the speed of diagnostic information during endoscopic biopsies, potentially enhancing patient management by reducing the time needed to diagnose lung cancer.
Comparative yield of EBUS-TBNA with EBUS-IFBTLP for diagnosis of mediastinal lymphadenopathy.
Ther Adv Respir Dis
September 2024
Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510145, China.
Article Synopsis
- The study investigates the effectiveness of a new biopsy technique (EBUS-IFB-TLP) compared to the standard method (EBUS-TBNA) for diagnosing mediastinal lymph node enlargement (MLNE) in patients suspected of having lung cancer or other conditions.
- Conducted from January 2020 to December 2022 with 67 patients, the results showed that EBUS-IFB-TLP had a higher diagnostic yield (97.0% vs. 85.1%) and diagnosed more cases of lung cancer and sarcoidosis.
- Both methods were associated with some bleeding complications, with EBUS-IFB-TLP showing a slightly higher rate (23.9% vs. 14.9
A rare case report of endobronchial neurofibroma treated with transbronchial endoscopic resection and literature review.
Medicine (Baltimore)
September 2024
Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Zhejiang Province, China.
Article Synopsis
- Endobronchial neurofibroma is a super rare type of tumor in the lungs that can cause symptoms like coughing and shortness of breath.
- A 57-year-old man was diagnosed with this condition and his tumor was successfully removed using special tools without needing traditional surgery.
- This case shows that new methods like electrical snaring and laser treatments can work well for certain lung tumors and could help other patients with similar issues.
Assessment of needle-based confocal laser endomicroscopy (nCLE) as a tool for real-time diagnosis of non-small cell lung cancer.
J Thorac Dis
August 2024
Thoracic Surgery Department, University Hospital Nancy, Nancy, France.
Background: The widespread deployment of screening programs has increased the number of suspected pulmonary nodules diagnosed. The main objective of this retrospective study was to evaluate the concordance between needle-based confocal laser endomicroscopy (nCLE) image patterns and pathology reports.
Methods: In this retrospective study, we reviewed all cases of endobronchial navigational bronchoscopy (ENB) performed using the nCLE system as a guide for injecting a dye marker or for biopsy of a lung nodule.
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