Towards a Clinically Valid Mechanistic Assessment of Exposure and Response Prevention: Preliminary Utility of an Exposure Learning Tool for Children with OCD.

J Obsessive Compuls Relat Disord

Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, 6363 Alvarado Court, Suite 102, San Diego, CA 92120.

Published: April 2020

Despite advances in understanding mechanisms underlying fear processes, there remains a significant gap between insights produced via laboratory assessment and concrete tools for harnessing these insights in clinical practice. In addressing this gap, researchers would ideally introduce tools that are feasible for patients in clinical practice, easily disseminated to practitioners, and clinically useful. We present pilot data on the Exposure Experience Questionnaire (EEQ), a brief measure designed to assess exposure learning mechanisms. Ten children (ages 8-15) with a primary diagnosis of obsessive-compulsive disorder (OCD) underwent exposure and response prevention in which they completed weekly exposures in clinic and at home. During each exposure, children completed an exposure practice form which included the EEQ. Results suggest the preliminary feasibility and internal consistency of this measure, with comparable utility in clinic and home settings. The EEQ was associated in the expected direction with slope of OCD symptoms, such that greater exposure learning in both clinic and homework exposures predicted improved outcome. Although limited by small sample size, these data support the continued research on the feasibility and utility of the EEQ and suggest that quantifying learning processes following exposure may be a useful addition to mechanistic research in OCD.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271823PMC
http://dx.doi.org/10.1016/j.jocrd.2020.100528DOI Listing

Publication Analysis

Top Keywords

exposure learning
12
exposure
9
exposure response
8
response prevention
8
clinical practice
8
clinically valid
4
valid mechanistic
4
mechanistic assessment
4
assessment exposure
4
prevention preliminary
4

Similar Publications

A Collaborative Online International Learning Experience for Doctoral Nursing Students and Faculty From Three Countries: Reshaping the Educational Landscape.

Nurs Educ Perspect

October 2024

About the Authors Judith Bacchus Cornelius, PhD, RN, FAAN, ANEF, is a professor, College of Health and Human Services, University of North Carolina at Charlotte, Charlotte, North Carolina. Charlene Downing, PhD, RN, is a professor, Department of Nursing, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa. Adesola A. Ogunfowokan, PhD, RN, FWACN, is a professor, Community Health Nursing, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria. Nompumelelo Ntshingila, DCur(UJ), is an associate professor, Department of Nursing, Faculty of Health Sciences, University of Johannesburg. Florence Okoro, PhD, RN, is an associate professor, College of Health and Human Services, University of North Carolina at Charlotte. Ijeoma Enweana, DNP, RN, CVN, is adjunct nursing faculty, Presbyterian School of Nursing, Queens University of Charlotte, Charlotte, North Carolina. Oluwayemisi Olagunju, PhD, is senior lecturer, Department of Nursing Science, Obafemi Awolowo University. Funding was received from the University of North Carolina at Charlotte Global Learning and Internationalization Institute. For more information, contact Dr. Cornelius at

The COVID-19 pandemic presented opportunities for educational innovations and the development of intercultural learning experiences. A global health assignment guided by a collaborative online international learning pedagogy was assigned to doctoral nursing students from three different countries. Icebreaker activities, along with the Culturally You diagram, commenced the team-building process.

View Article and Find Full Text PDF

Background: High consequence infectious diseases (HCID) include contact-transmissible viral haemorrhagic fevers and airborne-transmissible infections such as Middle Eastern Respiratory Syndrome. Assessing suspected HCID cases requires specialised infection control measures including patient isolation, personal protective equipment (PPE), and decontamination. There is need for an accessible course for NHS staff to improve confidence and competence in using HCID PPE outside specialist HCID centres.

View Article and Find Full Text PDF

Background: Individual neurobiological heterogeneity among patients with tobacco use disorder (TUD) hampers the identification of neuroimaging phenotypes.

Methods: The current study recruited 122 TUD individuals and 57 healthy controls, and obtained their 3D-T1 images. Heterogeneity through discriminative analysis (HYDRA) was applied to uncover the potential subtype of TUD where regional gray matter volume (GMV) was treated as the feature.

View Article and Find Full Text PDF

Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2.

Ecotoxicol Environ Saf

December 2024

Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education (China Medical University), Shenyang, Liaoning 110122, China; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China. Electronic address:

Cadmium (Cd), a notorious environmental pollutant, has been linked to neurological disorders, but the underlying mechanism remains elusive. We aimed to explore the role of microglia in Cd-induced synaptic damages at environmentally relevant doses and whether microglia directly engulf synaptic structures. Nrf2 is deeply implicated in the status of microglial activation; therefore, we also investigated whether it is involved in the above process.

View Article and Find Full Text PDF

It has been reported that enrofloxacin (ENR) disrupts metabolic pathway of steroid in female crucian carp, promoting testosterone (T) synthesis through stimulating expression of luteinizing hormone (LH) and inhibiting conversion of T to estradiol (E) through repressing aromatase A expression. To further learn effect of ENR on steroid metabolism in fish, this work investigated effect of ENR on central E synthesis and the involved mechanisms in female crucian carp through evaluating contents of T and E in blood and brain, expression of secretogranin 2a (scg2a), gonadotrophin 2 β (gth 2β, namely LH) and aromatase B (cyp19a1b) genes in brain, and activation of PI3K/Akt pathway in brain of ENR exposed female crucian carp. Results revealed that ENR promoted steroid metabolism in brain of female crucian carp, stimulated synthesis of T synthesis but inhibited conversion of T to E through promoting expression of scg2a and gth 2β but repressing expression of cyp19a1b, PI3K/Akt signaling pathway participated in regulating the biological process.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!