Sekikaic acid modulates pancreatic β-cells in streptozotocin-induced type 2 diabetic rats by inhibiting digestive enzymes.

The antioxidant and antidiabetic effects of sekikaic acid were investigated using and study models. possessed good antioxidant activity as assessed through hydroxyl radicals (IC value = 41.5 µg/mL) and ferric ions assay (IC value = 42.0 µg/mL). exhibited stronger α-glucosidase and α-amylase inhibition than that of aldose-reductase and protein tyrosine phosphatase 1B. The hypoglycemic activity of caused significant reduction of plasma glucose levels in normal and glucose loaded rats. The anti-hyperglycemic activity of (2 mg/Kg body weight) was indicated by the reduction of blood glucose by 44.17 ± 3.78% in the third week in streptozotocin-induced diabetic rats. The hypolipidaemic action of was evident by the significant decrease in the levels of low-density lipoprotein, total cholesterol, and total glycerides. Histologically, the pancreas of the treated groups showed significant regeneration of the pancreatic β-cells compared to diabetic control, possibly due to the inhibition of digestive enzymes.