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Developing generic templates to shape the future for conducting integrated research platform trials.
Trials
March 2024
Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, 07936, USA.
Background: Interventional clinical studies conducted in the regulated drug research environment are designed using International Council for Harmonisation (ICH) regulatory guidance documents: ICH E6 (R2) Good Clinical Practice-scientific guideline, first published in 2002 and last updated in 2016. This document provides an international ethical and scientific quality standard for designing and conducting trials that involve the participation of human subjects. Recently, there has been heightened awareness of the importance of integrated research platform trials (IRPs) designed to evaluate multiple therapies simultaneously.
View Article and Find Full Text PDFPreface to the theme issue 'physics-informed machine learning and its structural integrity applications'.
Philos Trans A Math Phys Eng Sci
November 2023
MOE Key Laboratory of Deep Earth Science and Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, People's Republic of China.
The issue focuses on physics-informed machine learning and its applications for structural integrity and safety assessment of engineering systems/facilities. Data science and data mining are fields in fast development with a high potential in several engineering research communities; in particular, advances in machine learning (ML) are undoubtedly enabling significant breakthroughs. However, purely ML models do not necessarily carry physical meaning, nor do they generalize well to scenarios on which they have not been trained on.
View Article and Find Full Text PDFPreface to the 9th Biennial COAST Conference: Harnessing Technology and Biomedicine for Personalized Orthodontics.
Orthod Craniofac Res
December 2023
UCLA School of Dentistry, Los Angeles, California, USA.
Objective: The Consortium on Orthodontic Advances in Science and Technology (COAST) convened for its 9th biennial conference titled 'Harnessing Technology and Biomedicine for Personalized Orthodontics' to explore cutting-edge craniofacial research towards building the foundations for precision care in orthodontics.
Setting And Sample Population: Seventy-five faculty, scholars, private practitioners, industry, residents and students met at the UCLA Arrowhead Lodge on 6-9 November 2022 for networking, scientific presentations and facilitated discussions. Thirty-three speakers provided state-of-the-art, evidence-based scientific and perspective updates in craniofacial and orthodontic-related fields.
Preface: An update on superficial mesenchymal tumors: How the explosion of data translates into every day clinical practice.
Semin Diagn Pathol
July 2023
Memorial Sloan Kettering Cancer Center, Department of Pathology & Laboratory Medicine, NY, NY, United States. Electronic address:
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