AI Article Synopsis
- Endotoxemia is a serious illness that can be treated effectively with hemoperfusion, and there is a continuous need for better materials that can safely remove endotoxins.
- Researchers developed a fiber made from a complex of gellan-polylysine and polymyxin B, which binds specifically to endotoxins, resulting in strong fibers suitable for medical use.
- The fibers demonstrated excellent compatibility, showing no harmful effects on cells or blood, and effectively adsorbed endotoxins, making them promising candidates for use in hemoperfusion treatments.
Article Abstract
Endotoxemia, a life-threatening disease affecting people worldwide, can be treated by hemoperfusion alone. New hemoperfusion materials with high biocompatibility and endotoxin-combination ability are always in demand. Herein, polymyxin B (PMB), a specific endotoxin binding molecule, was loaded onto gellan-polylysine polyion complex, and the obtained material was used in preparing wet-spun fibers. The tensile strength of the as-spun yarns (100 fibers) ranged from 1.49 N to -1.58 N and that of the dried and rewetted yarns ranged from 1.45 N to 1.56 N. The adsorption ability of the fibers with lipopolysaccharides from E. coli was 2.784 ± 0.036 EU/mg in simulated human body fluid and 2.452 ± 0.107 EU/mg in mouse plasma. The fibers showed no cytotoxicity toward U2OS cells and no hemolysis toward mouse blood. The influence of the fibers on the clotting time of mouse blood was negligible, and the blood cells were not adhesive to the fibers. Thus, the PMB-loaded gellan-polylysine complex fiber and its derivate fabrics can be used in hemoperfusion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2020.05.263 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!