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Histone Deacetylation in Alzheimer's Diseases (AD); Hope or Hype.
Cell Biochem Biophys
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Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Histone acetylation is the process by which histone acetyltransferases (HATs) add an acetyl group to the N-terminal lysine residues of histones, resulting in a more open chromatin structure. Histone acetylation tends to increase gene expression more than methylation does. In the central nervous system (CNS), histone acetylation is essential for controlling the expression of genes linked to cognition and learning.
View Article and Find Full Text PDFBurying poultry carcasses on farms as a disposal option in crisis situations: learnings and perspectives from a field study during an avian influenza epizootic in France.
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Ploufragan-Plouzané-Niort Laboratory, Epidemiology Health and Welfare Unit, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), BP53 22440 Ploufragan, France. Electronic address:
Appropriate disposal of dead farming animals is required to guarantee effective disease control while protecting the environment. In crisis situations, alternatives to rendering can be used, including on-farm burial. The objectives of this study were to: (i) describe the burial and monitoring protocols used on poultry farms in France in response to major avian influenza outbreaks; (ii) assess the effectiveness of the burial protocol, in terms of both technical and biosecurity aspects, and microbiological, physical and chemical changes of the buried materials and the environment over time; (iii) provide recommendations for future burial and follow-up protocols.
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Division of Social Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China. Electronic address:
Early computational capacity sets the foundation for mathematical learning. Preschool children have been shown to perform both non-symbolic addition and subtraction problems. However, it is still unknown how different operations affect the representational precision of the non-symbolic arithmetic solutions.
View Article and Find Full Text PDFImpact of irrelevant speech and non-speech sounds on serial recall of verbal and spatial items in children and adults.
Sci Rep
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Center for Cognitive Science, Cognitive and Developmental Psychology Unit, University of Kaiserslautern-Landau (RPTU), 67663, Kaiserslautern, Germany.
Short-term memory for sequences of verbal items such as written words is reliably impaired by task-irrelevant background sounds, a phenomenon known as the "Irrelevant Sound Effect" (ISE). Different theoretical accounts have been proposed to explain the mechanisms underlying the ISE. Some of these assume specific interference between obligatory sound processing and phonological or serial order representations generated during task performance, whereas other posit that background sounds involuntarily divert attention away from the focal task.
View Article and Find Full Text PDFThromboembolism Risk Profiles in Non-valvular Atrial Fibrillation: How Can Machine Learning-Based Analysis Add to Our Understanding?
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Northwell, 2000 Marcus Ave., Suite 300, New Hyde Park, NY, 11042-1069, USA.
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