Revised reinforcement sensitivity theory (r-RST) of personality is a major neuropsychological theory of motivation, emotion and personality. This paper presents the results of a study examining: (1) the factor structure of the Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ) using confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM); and (2) the relationships of the r-RST constructs in the RST-PQ with attention deficit hyperactivity disorder (ADHD) symptom groups of inattention (IA) and hyperactivity/impulsivity (HI). A total of 572 (Sample 1) and 309 (Sample 2) adults completed the RST-PQ. Participants in Sample 2 also completed a questionnaire measuring ADHD symptoms. Results revealed more support for the ESEM model with six factors than the CFA model. For both the ESEM and CFA models, both IA and HI symptom groups were associated positively with the RST-PQ constructs of behavioral inhibition system (BIS) and behavioral approach system (BAS) Impulsivity, with IA also associated negatively with the BAS-Goal-Drive Persistence. The theoretical implications of these findings for understanding the factor structure of the RST-PQ, and for ADHD (IA and HI) in terms of r-RST, are discussed.
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http://dx.doi.org/10.1080/00223891.2020.1769113 | DOI Listing |
Atten Percept Psychophys
January 2025
Department of Psychology, The Ohio State University, 225 Psychology Building, 1835 Neil Ave, Columbus, OH, 43210, USA.
Humans can learn to attentionally suppress salient, irrelevant information when it consistently appears at a predictable location. While this ability confers behavioral benefits by reducing distraction, the full scope of its utility is unknown. As people locomote and/or shift between task contexts, known-to-be-irrelevant locations may change from moment to moment.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Department of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.
Unlabelled: Bioluminescence imaging (BLI) using engineered bioluminescent viruses has emerged as a powerful tool for real-time, noninvasive monitoring of viral replication in living animals. While traditional luciferase-based systems, such as firefly luciferase, have been widely used, the NanoLuc luciferase system offers distinct advantages, including its significantly smaller gene size, increased brightness, and independence from ATP as a cofactor, allowing for extracellular detection. However, the utility of NanoLuc has been limited by its traditional substrate, furimazine, which exhibits poor water solubility and potential cytotoxicity.
View Article and Find Full Text PDFJ Exp Anal Behav
January 2025
Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA.
Under rapid-acquisition, concurrent-chains choice procedures, psychomotor stimulants typically decrease the sensitivity of responding to changes in separate dimensions of reinforcement. Across two experiments, pigeons chose between outcomes that differed in terms of reinforcement delay and magnitude (the dimensions involved in delay discounting or "impulsive" choice; Experiment 1) or reinforcement probability and magnitude (the dimensions involved in probability discounting or "risky" choice; Experiment 2). Outcomes associated with each terminal link were varied independently and pseudorandomly across sessions such that in dominated sessions one terminal link was favorable in terms of both dimensions (sooner, larger in Experiment 1 and more likely, larger in Experiment 2) and in trade-off sessions each terminal link was favorable in terms of a different dimension.
View Article and Find Full Text PDFDrug Dev Res
February 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
We aimed to elucidate the prognostic and immunological roles of B cell-related genes in colorectal cancer (CRC). This study comprehensively integrated data from single-cell RNA-sequencing, TCGA, GEO, IMvigor210, GDSC, CancerSEA, HPA, and TISIDB databases to explore prognostic implications and immunological significance of B cell-related gene signature in CRC. We identified seven prognostically significant B cell-related genes for constructing a risk score.
View Article and Find Full Text PDFUnlabelled: Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors and social differences, both of which may manifest, in part, from underlying differences in corticostriatal circuits and reinforcement learning. Here, we investigated reinforcement learning in mice with mutations in either or , both high-confidence ASD risk genes associated with major syndromic forms of ASD. Using an odor-based two-alternative forced choice (2AFC) task, we tested adolescent mice of both sexes and found male and heterozygote (Het) mice showed enhanced learning performance compared to their wild type (WT) siblings.
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