Bioactivity-guided fractionation of the CHCl-soluble extract of the roots of was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.43 and 0.26 M, respectively. The -methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2020.1774760 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Research progress in alkaloids and their pharmacological effects from plants of Rutaceae].
Zhongguo Zhong Yao Za Zhi
November 2024
College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China.
The plants of Rutaceae, with wide distribution in China, have a long history of medicinal use. They contain a wide variety of alkaloids, which include isoquinolines, quinolines, acridones, carbazoles, and indoles. Pharmacological studies have shown that most of these alkaloids have antitumor, anti-inflammatory, antiviral, antidiabetic and other activities.
View Article and Find Full Text PDFSpectroscopic exploration of mode of binding of DNA and BSA with acridone alkaloids isolated from (Rutaceae).
Nat Prod Res
October 2024
Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, João Pessoa-Paraíba, Brazil.
is a medicinal plant widely studied due to its great phytochemical diversity, especially its acrinonic alkaloids, which have shown to be promising anticancer candidates. The aim of this work was to promote the isolation of acridonic alkaloids from fruits of and carried out absorption and fluorescence spectroscopy studies with calf thymus DNA and BSA. Five acridone alkaloids have been isolated, including the first description of 3-desmethoxy arborinine ().
View Article and Find Full Text PDFIn-silico and In-vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF-κB Inhibitors in Oral Cancer.
Chem Biodivers
October 2024
Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India.
Oral cancer is a global health concern, particularly because of its aggressive tissue invasion and metastases, holding 16 position on occurrence among all carcinoma worldwide. The aberrated transcription factor NF-κB1 influences development and spread of oral cancer, making it a potential therapeutic target. This study investigated the therapeutic potential of a few natural compounds from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla in the treatment of oral cancer.
View Article and Find Full Text PDFConchocarpus J. C. Mikan (Rutaceae): Chemical Constituents and Biological Activities.
Chem Biodivers
October 2024
Department of Chemistry, Universiade Federal de Minas Gerais, Av. Pres. Antonio Carlos, 6627, Campus Pampulha, CEP 31270-901, Belo Horizonte, MG, Brasil.
Rutaceae Juss. stands out as a botanical family recognized for its remarkable diversity in taxonomy, worldwide distribution, chemical composition, and biological activity exhibited by its compounds. Conchocarpus J.
View Article and Find Full Text PDFStructural, electronic, and NLO properties of two acridone alkaloîds: DFT and TD-DFT studies.
J Mol Model
August 2024
Department of Chemistry-Biology, Faculty of Science, University of Bertoua, P. O. Box 652, Bertoua, Cameroon.
Context: The structural, electronic, and nonlinear optical properties of Verdoocridone A (Ver A) and B (Ver B) are examined theoretically in this study. The results showed that Ver A and B exhibit good electronic properties and can be used as new materials in NLO applications. According to their maximum absorption wavelength, Ver A (λ = 313 nm) enables production of vitamin D, while Ver B (λ = 319.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!