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| http://dx.doi.org/10.14740/cr1065 | DOI Listing |
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Unclassifiable Renal Cell Carcinoma With an Estimated 100% Sarcomatoid Component: A Case Report.
Cureus
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Department of Anatomopathology, Mohammed VI University Hospital/Faculty of Medicine, Mohammed 1st University, Oujda, MAR.
Sarcomatoid renal cell carcinoma (RCC) is an aggressive tumour with a poor prognosis. It is not a distinct histological entity, as it can be found in any subtype of renal cell carcinoma. The majority of cases will present with advanced or metastatic disease requiring systemic treatment.
View Article and Find Full Text PDFenhances virulence by progressive generation of new phenotypes.
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November 2024
Bacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac Street 10, 08037, Barcelona, Spain.
and have been co-isolated from several biofilm-associated diseases, including those related to medical devices. This association confers advantages to both microorganisms, resulting in detrimental effects on the host. To elucidate this phenomenon, the present study investigated colony changes derived from non-physical interactions between and .
View Article and Find Full Text PDFThrough thick and thin: confronting the aggressive cutaneous T-cell lymphomas.
Hematology Am Soc Hematol Educ Program
December 2024
Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
The cutaneous T-cell lymphomas (CTCLs) comprise a diverse set of diseases with equally diverse presentations ranging from asymptomatic solitary lesions to highly aggressive diseases with propensity for visceral spread. The more aggressive CTCLs, which herein we consider as certain cases of advanced-stage mycosis fungoides/Sézary syndrome (MF/SS), primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (PCAETCL), and primary cutaneous gamma delta T-cell lymphoma (PCGDTCL), require systemic therapy. Over the last 5 years, treatment options for MF/SS have expanded with biological insights leading to new therapeutic options and increasingly unique management strategies.
View Article and Find Full Text PDFA rare case of atypical teratoid rhabdoid tumor at the sellar region in an adult: Case report and review of literature.
Brain Spine
November 2024
Department of Neurosurgery, General Hospital of Nikaia 'Agios Panteleimon', 18454, Athens, Greece.
Article Synopsis
- Atypical teratoid/rhabdoid tumor (AT/RT) is a rare brain cancer mainly found in children, but can appear in adults, especially in the sellar region of middle-aged women.
- A case study is presented of a 51-year-old woman with AT/RT who had headaches and left ptosis, leading to a diagnosis and treatment that included surgery, radiation, and chemotherapy.
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Stress enhances aggression in male rats with genetic stress hyper-reactivity.
Genes Brain Behav
October 2024
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Article Synopsis
- - The study examined how stress influences aggression in two genetically distinct male mouse strains: the stress-hyper-reactive Wistar Kyoto More Immobile (WMI) and the control Wistar Kyoto Less Immobile (WLI), using a resident-intruder test.
- - Prior acute stress led to decreased social interactions and aggression in adult WLIs, but increased aggression in stressed adult WMIs toward both same-age and juvenile intruders, indicating a genetic predisposition to stress-induced aggression.
- - Genetic analysis revealed alterations in aggression-related genes between strains, with specific changes in the frontal cortex and amygdala of WMIs after stress, suggesting that their genetic makeup contributes to heightened aggression under stress, potentially opening pathways for future research on
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