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Pre-mRNA Splicing in the Nuclear Landscape. | LitMetric

Pre-mRNA Splicing in the Nuclear Landscape.

Cold Spring Harb Symp Quant Biol

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.

Published: June 2020

AI Article Synopsis

Article Abstract

Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding regions in pre-mRNA, must be removed by the spliceosome, which assembles on the pre-mRNA as it is transcribed by RNA polymerase II (Pol II). The assembly and activity of the spliceosome can be modulated by features including the speed of transcription elongation, chromatin, post-translational modifications of Pol II and histone tails, and other RNA processing events like 5'-end capping. Here, we review recent work that has revealed cooperation and coordination among co-transcriptional processing events and speculate on new avenues of research. We anticipate new mechanistic insights capable of unraveling the relative contribution of coupled processing to gene expression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384967PMC
http://dx.doi.org/10.1101/sqb.2019.84.040402DOI Listing

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