AI Article Synopsis
- Matrix metalloproteinases (MMPs) are key players in tumor growth and spread, and the compound 4'-geranyloxyferulic acid (GOFA) shows promise for its anti-tumor and anti-inflammatory effects.
- In experiments with U937 and HCT116 cancer cells, GOFA was found to reduce abnormal cell growth and MMP-9 activity caused by lipopolysaccharide (LPS), leading to decreased cell migration.
- The study suggests that GOFA's ability to inhibit the ROS/ERK pathway and prevent apoptosis and senescence may make it a valuable therapeutic option to combat tumor metastasis.
Article Abstract
Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4'-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell survival, invasion, and migration through reactive oxygen species (ROS)-mediated MMPs activation of extracellular signal-regulated kinases (ERKs) and p38 signaling in lymphocytic histiocytoma (U937) and colorectal cancer (HCT116) cells. We observed that lipopolysaccharide (LPS) stimulated U937 and HCT116 cells presented abnormal cell proliferation and increased metalloproteinase (MMP-9) activity and expression. Non-cytotoxic doses of GOFA blunted matrix invasive potential by reducing LPS-induced MMP-9 expression and cell migration via inhibiting ROS/ ERK pathway. GOFA also attenuated apoptosis and cell senescence. Our findings indicate that GOFA, inhibiting cancer cell proliferation and migration, could be therapeutically beneficial to prevent tumor metastasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346147 | PMC |
| http://dx.doi.org/10.3390/antiox9060470 | DOI Listing |
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