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The strategy to control the outbreak of an emerging respiratory infectious disease in a simulated Chinese megacity.
Heliyon
January 2025
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Objectives: The emergence of respiratory infectious diseases (ERID) poses a significant threat to global public health. However, effectively managing ERID outbreaks in large cities remains a challenge.
Methods: An age-structured Susceptible-Exposed-Infectious-Removed (SEIR) model was developed to predict the effectiveness of non-pharmaceutical interventions (NPIs) in controlling ERID outbreaks.
Sequence Notes: Identification of Three Novel HIV-1 Recombinant Strains with Different Recombination Patterns in Hebei Province, China.
AIDS Res Hum Retroviruses
January 2025
Clinical Laboratory of the People's Hospital of Baoding, Baoding, China.
The global human immunodeficiency virus 1 (HIV-1) pandemic is driven by the extraordinary genetic diversity of the virus, largely resulting from frequent recombination events. These events generate circulating recombinant forms (CRFs) and unique recombinant forms, which significantly contribute to the complexity of HIV-1 epidemiology, especially within key populations, such as men who have sex with men (MSM). Here, we identified three novel HIV-1 recombinant strains consisting of the CRF01_AE and CRF07_BC subtypes from HIV-positive MSM in Baoding City, Hebei Province, China.
View Article and Find Full Text PDFEndothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts.
Adv Sci (Weinh)
January 2025
Clinical Research Center, Postdoctoral Station of Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, P. R. China.
Vascular calcification is a highly regulated process in cardiovascular disease (CVD) and is strongly correlated with morbidity and mortality, especially in the adverse stage of vascular remodeling after coronary artery bypass graft surgery (CABG). However, the pathogenesis of vascular graft calcification, particularly the role of endothelial-smooth muscle cell interaction, is still unclear. To test how ECs interact with SMCs in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression.
View Article and Find Full Text PDFUnraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine.
Annu Rev Pathol
January 2025
MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA; email:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem, affecting ∼1 billion people. This condition is well established to have a heritable component with strong familial clustering. With the extraordinary breakthroughs in genetic research techniques coupled with their application to large-scale biobanks, the field of genetics in MASLD has expanded rapidly.
View Article and Find Full Text PDFPublic Health Travel Restrictions Implemented for Persons at Risk of Transmitting SARS-CoV-2 Infection-United States, January 1, 2020-April 6, 2022.
J Public Health Manag Pract
January 2025
Author Affiliations: Division of Global Migration Health, Centers for Disease Control and Prevention (Ms Surpris, Ms Jungerman, Dr Preston, Dr Gertz, Ms Duong, Dr Roy, Ms Morales, Mr Olmstead, Ms Delea, Dr Alvarado-Ramy, Dr Brown, and Dr Chen); Council of State and Territorial Epidemiologist (CSTE) Fellow, Atlanta, Georgia (Mr Olmstead); and University of South Florida, Tampa, Florida (Ms Surpris).
Context: Federal public health travel restrictions (FPHTR) in the United States are implemented for persons who meet specific criteria to prevent spread of communicable diseases of public health concern. FPHTR can mitigate the risk of disease transmission during air travel and mitigating disease translocation between geographic areas.
Objective: To characterize and determine the extent of FPHTR implementation during the COVID-19 pandemic.
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