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Galectin-3 Levels in Patients with Chronic Constrictive Pericarditis. | LitMetric

AI Article Synopsis

  • Galectin-3 (Gal-3) is a molecule linked to inflammation and fibrosis in heart failure, and its role in chronic constrictive pericarditis (CCP) has not been well understood.
  • This study involved 25 patients with CCP and 21 healthy controls, measuring Gal-3 and other clinical parameters before and after surgery (pericardiectomy) to see if Gal-3 levels correlated with their condition.
  • Results showed that Gal-3 levels were normal and similar in both groups, with no significant correlations to clinical measures before surgery, but suggested potential associations with exercise ability afterwards, indicating it might help predict outcomes post-surgery.

Article Abstract

Background Galectin-3 (Gal-3) is a proinflammatory, profibrotic molecule implicated in the pathogenesis of heart failure. The role of Gal-3 in patients with chronic constrictive pericarditis (CCP) is not clear. Objective The aim of this study was to assess plasma Gal-3 in patients with CCP and correlate it with clinical, functional and histologic parameters. Methods We prospectively evaluated 25 symptomatic patients with CCP referred for pericardiectomy and 21 healthy controls. Patients underwent clinical assessment, Gal-3 and B-type natriuretic peptide (BNP) measurements, echocardiography, cardiac magnetic resonance imaging and cardiopulmonary exercise test (CPET) at baseline. Six months after pericardiectomy CPET was repeated. An alpha error < 5% was considered statistically significant, with a confidence interval of 95%. Results Twenty-five patients with a median age of 45 years were included. Etiology was mainly idiopathic (n = 19, 76%); and 14 (56%) patients had NYHA functional class III/IV. Median BNP and Gal-3 were 143 (89-209) pg/dL and 14.8 (9.7-17.2) ng/mL, respectively. Gal-3 levels were not significantly higher in CCP patients than in control (p = 0.22). There were no significant correlations of Gal-3 with BNP, echocardiographic and cardiac magnetic resonance measures and histological findings. After pericardiectomy, it was found a statistically significant correlation between Gal-3 and the CPTE measures test duration (r = -0.79; p < 0.001) and exercise time (r = -0.79; p < 0.001). Conclusions Patients with CCP had normal levels of Gal-3 as compared to the controls. Gal-3 did not correlate with morphological and functional measures before pericardiectomy. However, the associations between Gal-3 and exercise intolerance after pericardiectomy may suggest a role of Gal-3 in prognosis prediction after pericardiectomy. (Arq Bras Cardiol. 2020; 114(4):683-689).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744340PMC
http://dx.doi.org/10.36660/abc.20190152DOI Listing

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