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Viral sepsis is rare, and its real incidence is not known. SARS-CoV-2 infection causes the release of a significant amount of pro-inflammatory cytokines that aggravates interstitial pneumonia and evolves in viral sepsis with prominent hypercoagulability. We believe it is useful and advisable to establish early immunomodulator therapy and the prophylaxis anticoagulant therapy should be rethought.
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http://dx.doi.org/10.1177/0025817220926915 | DOI Listing |
J Heart Lung Transplant
February 2025
CEA, DRF-Institut de Biologie Francois Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France; U976 HIPI, IRSL, Université Paris Cité, Paris, France.
J Viral Hepat
April 2025
Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Real-time polymerase chain reaction (PCR) is the current standard for serum HBV DNA measurement. However, conventional real-time PCR assays have technical limitations, and are not sensitive enough to detect low-level residual viremia in chronic hepatitis B (CHB) patients. We developed and validated a droplet digital PCR (ddPCR) assay for high-sensitivity detection of serum HBV DNA.
View Article and Find Full Text PDFTop Companion Anim Med
March 2025
Department of Biostatistics, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, 31060, Hatay, Turkey.
Canine parvoviral enteritis (CPE) is a highly contagious, acute viral disease that mainly affects young dogs and can lead to systemic inflammatory response syndrome (SIRS), sepsis, endotoxemia and even death. The study aimed to evaluate the diagnostic and prognostic potential of hematological indices such as MLR, NLR, PLR, PNR and SII in CPV-infected dogs with SIRS at first admission. The retrospective study was performed on 51 CPV-infected and 20 healthy dogs.
View Article and Find Full Text PDFVet Microbiol
March 2025
Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China; Key Laboratory of Biotechnology and Bioengineering of State Ethnic Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China; School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730030, China. Electronic address:
The outbreak and prevalence of encephalomyocarditis virus (EMCV) causes significant global mortality and morbidity to the pig industry. Though the current and most effective approach to control EMCV outbreak are done through inactivated vaccines, we have yet to see an effective antiviral agent that directly targets EMCV. Here, we present a molecular therapy consisting of extracellular vesicles (EVs) decorated with EMCV-specific single-chain variable fragment (scFv), engineered on the external loop of the EVS transmembrane domain CD63.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
March 2025
Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
The temporal coincidence of a tick- and rodent-associated disease led to a confusing variety of symptoms, which posed diagnostic challenges. A 51-year old otherwise healthy patient developed high fever, pronounced cephalgia and acute renal failure a few days after the onset of erythema migrans. Bradycardia and other cardiac symptoms with left ventricular failure occurred in the course of the disease, which were interpreted as Lyme carditis.
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