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Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model. | LitMetric

AI Article Synopsis

  • - The study aimed to investigate the effects of Ankaferd Blood Stopper (ABS) on wound healing in Wistar albino rats by comparing three different treatment methods: primary suturing, secondary healing, and ABS application.
  • - Results showed that ABS application led to wound healing with similar strength to direct suturing, but there was a significant difference in healing compared to leaving the wound open.
  • - The study concluded that while ABS promotes effective wound healing and enhances fibroblast activity, further research is needed to assess the long-term outcomes of its application.

Article Abstract

Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing.

Materials And Methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program. P < 0.05 was considered significant.

Results: The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3, respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score, mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003).

Conclusions: ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491291PMC
http://dx.doi.org/10.3906/sag-2004-177DOI Listing

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