Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by proliferation of immature myeloid cells, with impaired differentiation and maturation. Spinster homolog (SPNS) is a widely distributed transmembrane transporter, which assists sphingolipids in playing their roles through the cell membrane. However, the expression and clinical implication of the family has not been investigated in AML. From the Cancer Genome Atlas database, a total of 155 AML patients with complete clinical characteristics and expression data were contained in our study. In patients who received chemotherapy only, high expressions of and had adverse effects on event-free survival (EFS) and overall survival (OS) (all <0.05). However, in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) group, we only found a significant difference in OS between the high and low expression groups (=0.001), while other members showed no effect on survival. Multivariate analysis indicated that high expression was an independent risk factor for both EFS and OS in chemotherapy patients. The results confirmed that high expression of and were poor prognostic factors, and the effect of can be neutralized by allo-HSCT.
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| http://dx.doi.org/10.7150/jca.44766 | DOI Listing |
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