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Blood-based Markers in the Prognostic Prediction of Esophagogastric Junction Cancer. | LitMetric

AI Article Synopsis

  • Esophagogastric junction cancer is a significant health threat in both Western countries and East Asia, especially in China and Japan, with increasing incidence and low 5-year survival rates compared to other gastric cancers.
  • The traditional TNM staging system for prognosis relies on surgical and imaging methods, while newer research is exploring non-invasive blood-based markers for better prognostic evaluation.
  • This article reviews studies examining the prognostic value of blood markers, including hematologic and biochemical parameters, tumor-associated antigens, microRNAs, and circulating tumor cells, particularly in adenocarcinoma subtype of esophagogastric junction cancer.

Article Abstract

Esophagogastric junction cancer poses a great threat to human beings both in western countries and East Asia, especially in China and Japan, and its incidence has increased during recent decades. The 5-year survival rate of esophagogastric junction cancer is quite poor compared with that of other gastric cancer sites. Until now, the traditional TNM staging system has been widely used in clinical practice for prognosis. However, the TNM system is based on pathology after surgical resection or radiology using CT and MRI, not on blood markers. Evidently, some research has been reported concentrated on the prognostic value of blood-based markers with the character of non-invasive and non-radioactive in EJA. Hematologic, biochemical and coagulation parameters could be obtained from clinical data and utilized to analyze their prognostic values. Tumor-associated antigens, microRNAs and circulating tumor cells have also been reported in EJC prognosis. In this article, we review research focused on blood-based markers to evaluate their prognostic value in esophagogastric junction cancer, especially its main subtype adenocarcinoma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255356PMC
http://dx.doi.org/10.7150/jca.44545DOI Listing

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