Dignity is a concept we often evoke in healthcare when caring for patients and attending to their basic needs. It is a very human concept, unique perhaps. Yet, though instinctively we think we know what it means, we rarely pause to reflect on it. What does it mean? It is a concept that is hard to define and not easy to apply and yet a concept important for humanity. This article explores the roots and the uses of the term with particular reference to human rights, patient choices at the end of life and to vulnerability.
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Mycobacterium tuberculosis (M.tb) infection can lead to various outcomes, including active tuberculosis or latent tuberculosis infection (LTBI). Household contacts of TB cases have a high risk of acquiring LTBI.
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Data61, CSIRO, Clayton, VIC, 3168, Australia.
The rapid growth of Internet of Things (IoT) devices necessitates efficient data compression techniques to manage the vast amounts of data they generate. Chemiresistive sensor arrays (CSAs), a simple yet essential component in IoT systems, produce large datasets due to their simultaneous multi-sensor operations. Classical principal component analysis (cPCA), a widely used solution for dimensionality reduction, often struggles to preserve critical information in complex datasets.
View Article and Find Full Text PDFAm J Dermatopathol
February 2025
Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
Methotrexate (MTX), an antimetabolite targeting certain autoimmune conditions and various hematologic malignancies, has been associated with iatrogenic lymphoproliferative disease (LPD) primarily of B-cell lineage. Less commonly are T-cell neoplasms where primary skin involvement is considered rare. Three cases were encountered in the medical practice of one of the authors.
View Article and Find Full Text PDFEntropy (Basel)
January 2025
Department of Computer Science, Bay Campus, Fabian Way, Swansea University, Swansea SA1 8EN, UK.
Classic formulae for entropy and cross-entropy contain operations x0 and log2x that are not defined on all inputs. This can lead to calculations with problematic subexpressions such as 0log20 and uncertainties in large scale calculations; partiality also introduces complications in logical analysis. Instead of adding conventions or splitting formulae into cases, we create a new algebra of real numbers with two symbols ±∞ for signed infinite values and a symbol named ⟂ for the undefined.
View Article and Find Full Text PDFCells
January 2025
Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Hemophilia A (HA) is associated with FVIII coagulation insufficiency or inactivity leading to excessive bleeding. Elevated FVIII, on the contrary, is associated with thrombophilia, thrombosis, myocardial infarctions, and stroke. Active FVIII (aFVIII) uses its C2 domain to bind to blood cells' membranes, consequently carrying out its coagulative function.
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