Introduction: Adalimumab and etanercept are drugs used in anti-TNF therapy in patients with psoriasis and psoriatic arthritis. Despite the molecular targeting of these drugs, the loss of pharmacological response to treatment is observed in patients. The development of personalized medicine makes it possible to use not only clinical parameters of disease severity, but also molecular marker systems.
Aim: The aim of the study was to evaluate the changes in α, , and expression in relation to parameters of disease severity (PASI, BSA, DAS28) in patients treated with adalimumab and etanercept. We have attempted to determine whether changes in the α, , and expression profile may be a useful molecular marker of the therapeutic potential of anti-TNF drugs.
Material And Methods: The study group consisted of 3 patients initially treated with adalimumab, followed by etanercept. The control group included 20 healthy volunteers. The expression profile of and was determined at the mRNA level, while α expression was evaluated at the transcriptome and proteome levels using the RT-qPCR method (transcriptional activity assay) and MALDI-TOF MS (protein level assessment).
Results: Depending on the drug, different expression profiles of the studied cytokines are observed.
Conclusions: The obtained data indicate that α, , and may be useful markers of the efficacy of anti-TNF therapy, thus complementing clinical parameters.
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| http://dx.doi.org/10.5114/ada.2020.94847 | DOI Listing |
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