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Hypercalcemia-Driven Spontaneous Tumor Lysis Syndrome in a Case of Recently Diagnosed Multiple Myeloma: An Unusual Clinical Encounter.
Cureus
September 2024
Hematology, Universidad Autonoma de Nuevo Leon, Monterrey, MEX.
Article Synopsis
- - Tumor lysis syndrome (TLS) is an emergency caused by rapid breakdown of cancer cells from treatment, leading to release of harmful substances into the bloodstream, but spontaneous TLS (STLS) can occur without clear triggers.
- - A case study of a 74-year-old man showed STLS with complications like hypercalcemia and hyperuricemia after being diagnosed with multiple myeloma, illustrated by his symptoms and imaging findings.
- - The report emphasizes the importance of identifying high-risk patients for STLS, recognizing potential associated factors, and highlights necessary diagnostic and treatment strategies for clinicians to prevent severe complications.
A case report navigating CVID and sarcoidosis overlaps in pediatric nephritis.
Front Pediatr
September 2024
Division of Immunology, Allergy, and Retrovirology, Department of Pediatrics, Baylor College of Medicine, William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, United States.
Article Synopsis
- A 13-year-old boy diagnosed with common variable immunodeficiency (CVID) has complicated health issues like a skin rash and abnormal laboratory results, including low blood cell counts and high calcium levels.
- Tests to find infections didn’t show anything, but a scan revealed swollen lymph nodes and lung problems.
- After receiving treatment for conditions that looked like sarcoidosis, he didn’t respond well, and doctors found out he also had lung disease (GLILD) and pneumonia caused by a virus.
Primary Hepatic Lymphoma: A Rare Form of Diffuse Large B-Cell Lymphoma of the Liver.
Fed Pract
May 2023
Veterans Affairs Eastern Kansas Health Care System, Topeka.
Background: Primary hepatic lymphoma is a rare, malignant lymphoma of the liver unlike the predominant lymph nodal or splenic involvement associated with other types of lymphoma. It is commonly associated with nonspecific symptoms and usually detected incidentally on imaging examination.
Case Presentation: An 84-year-old man was evaluated for upper back pain.
Although suggested in early papers, the association between primary hyperparathyroidism (PHPT) and hyperuricemia is still debated, as is the potential benefit of parathyroidectomy compared to conservative treatment in serum uric acid (SUA) metabolism. Material and Our retrospective study of 125 Caucasian PHPT patients with surgical criteria evaluated between 2017 and 2021 at Elias Emergency and University Hospital, Bucharest, Romania aims to describe the characteristics of hyperuricemia in PHPT patients and to assess the differences in SUA levels between 38 surgically cured and 41 conservatively managed patients. Our hyperuricemic PHPT patients (N=34) had significantly higher levels of calcium (11.
View Article and Find Full Text PDFMalignant hypercalcemia as the debut of acute lymphoblastic leukemia in a pediatric patient-a diagnostic and therapeutic approach: Case report.
Front Pediatr
November 2022
Department of Pediatrics, Fundación Santa Fe de Bogotá University Hospital, Universidad de los Andes, Bogotá, Colombia.
Background: Hypercalcemia is a rare metabolic disorder in the pediatric population, with several differential diagnoses that resemble hematologic malignancies. In cases of severe hypercalcemia, therapeutic strategies other than hyperhydration, such as the use of bisphosphonates, have been described.
Case Presentation: We present the case of a previously healthy 12-year-old boy who was admitted to the emergency department due to fatigue, hypo-responsiveness, and progressively worsening poor appetite for the previous 19 days.
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