Brain tumor vessels-a barrier for drug delivery.

Cancer Metastasis Rev

Dept of Health Technology, Technical University of Denmark, 2800, Kgs Lyngby, Denmark.

Published: September 2020

Cancer treatment remains a challenge due to a high level of intra- and intertumoral heterogeneity and the rapid development of chemoresistance. In the brain, this is further hampered by the blood-brain barrier that reduces passive diffusion of drugs to a minimum. Tumors grow invasively and form new blood vessels, also in brain tissue where remodeling of pre-existing vasculature is substantial. The cancer-associated vessels in the brain are considered leaky and thus could facilitate the transport of chemotherapeutic agents. Yet, brain tumors are extremely difficult to treat, and, in this review, we will address how different aspects of the vasculature in brain tumors contribute to this.

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Source
http://dx.doi.org/10.1007/s10555-020-09877-8DOI Listing

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